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snx10a sorting nexin 10a [ Danio rerio (zebrafish) ]

Gene ID: 403027, updated on 4-Jan-2025

Summary

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Official Symbol
snx10aprovided by ZNC
Official Full Name
sorting nexin 10aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050809-44
See related
Ensembl:ENSDARG00000004405 AllianceGenome:ZFIN:ZDB-GENE-050809-44
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Snx10; im:7153949
Summary
Predicted to enable phosphatidylinositol phosphate binding activity. Involved in Kupffer's vesicle development; cilium assembly; and left/right axis specification. Acts upstream of or within heart looping. Predicted to be located in cytoskeleton and endosome membrane. Predicted to be active in endosome. Predicted to colocalize with centrosome. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 8. Orthologous to human SNX10 (sorting nexin 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See snx10a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (18118359..18130463, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (18655506..18664778, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene pyroglutamylated RFamide peptide Neighboring gene integrator complex subunit 8 Neighboring gene uncharacterized LOC103911055 Neighboring gene chromobox homolog 3a (HP1 gamma homolog, Drosophila)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Chen Y, et al. Cell Res, 2012 Feb. PMID 21844891, Free PMC Article
  2. Deep sequencing of the zebrafish transcriptome response to mycobacterium infection. Hegedus Z, et al. Mol Immunol, 2009 Sep. PMID 19631987
  3. The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. Li JY, et al. J Biol Chem, 2020 Jan 24. PMID 31852739, Free PMC Article
  4. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
  5. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Kupffer's vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within left/right axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in left/right axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-10A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139462.1 → NP_001132934.1  sorting nexin-10A

    See identical proteins and their annotated locations for NP_001132934.1

    Status: VALIDATED

    Source sequence(s)
    BC055622, BM184815, EH537271
    UniProtKB/Swiss-Prot
    F1Q506, Q7SXF9
    UniProtKB/TrEMBL
    A0A8M9P1S3
    Related
    ENSDARP00000098673.2, ENSDART00000108627.5
    Conserved Domains (1) summary
    cd06898
    Location:13 → 125
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    18118359..18130463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468032.2 → XP_021323707.1  sorting nexin-10A isoform X1

    UniProtKB/Swiss-Prot
    F1Q506, Q7SXF9
    UniProtKB/TrEMBL
    A0A8M9P1S3
    Related
    ENSDARP00000025688.7, ENSDART00000022803.8
    Conserved Domains (1) summary
    cd06898
    Location:13 → 125
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1Q506.1 GenPept UniProtKB/Swiss-Prot:F1Q506

Gene LinkOut

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