ezra ezrin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ezraprovided by ZNC
Official Full Name: ezrin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-18
See related: Ensembl:ENSDARG00000020944 AllianceGenome:ZFIN:ZDB-GENE-050522-18
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Moe; ezrl; vil2l; wu:fb02d02; zgc:110666
Summary: Predicted to enable actin binding activity and cell adhesion molecule binding activity. Predicted to be involved in several processes, including positive regulation of early endosome to late endosome transport; positive regulation of protein localization to early endosome; and regulation of cell shape. Predicted to be located in several cellular components, including apical plasma membrane; cell cortex; and cell projection membrane. Predicted to be active in several cellular components, including adherens junction; filopodium; and microvillus. Orthologous to human EZR (ezrin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (45413634..45450150)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (45430382..45466898)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELMO-DOCK1, a bipartite guanine nucleotide exchange factor complex for the small GTPase Rac1, and for the membrane-cytoskeletal linker Ezrin, regulates centriole/basal body migration, docking and spacing.
Title: The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin.
mosaic eyes (moe) function is required for tight junction formation in the retinal pigmented epithelium.
Title: Zebrafish mosaic eyes is a novel FERM protein required for retinal lamination and retinal pigmented epithelial tight junction formation.
By performing genetic mosaic analyses, study shows that moe- rod photoreceptors have greatly expanded apical structures, suggesting that Moe is a negative regulator of Crumbs protein function in photoreceptors.
Title: Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size.
Expression of the band 4.1/FERM domain gene mosaic eyes in podocytes is required for proper formation of slit-diaphragm cell-cell junctions.
Title: Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes.

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General gene information

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Markers

fc58h06.y1 (e-PCR)
- UniSTS:194131

fb02d02.y1 (e-PCR)
- UniSTS:189810

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in developmental process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ezrin a

Names: ezrin like; ezrin1; villin 2 (ezrin) like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020490.1 → NP_001018326.1 ezrin a

See identical proteins and their annotated locations for NP_001018326.1

Status: PROVISIONAL

Source sequence(s)

BC095359

UniProtKB/TrEMBL

B2GTD8, F6P0P9, Q503E6

Related

ENSDARP00000108896.2, ENSDART00000124911.4

Conserved Domains (5) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:91 → 206

FERM_M; FERM central domain

pfam00769
Location:347 → 595

ERM; Ezrin/radixin/moesin family

pfam09379
Location:9 → 71

FERM_N; FERM N-terminal domain