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bace1 beta-secretase 1 [ Danio rerio (zebrafish) ]

Gene ID: 403005, updated on 4-Jan-2025

Summary

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Official Symbol
bace1provided by ZNC
Official Full Name
beta-secretase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1835
See related
AllianceGenome:ZFIN:ZDB-GENE-040426-1835
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77409
Summary
Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within myelination in peripheral nervous system and positive regulation of myelination. Predicted to be located in several cellular components, including Golgi apparatus; endosome; and membrane raft. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Is expressed in brain. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See bace1 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (91018..97433, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (16447..22862, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-83n3.2 Neighboring gene AXL receptor tyrosine kinase Neighboring gene uncharacterized LOC103908784 Neighboring gene T-box transcription factor TBX1 Neighboring gene apolipoprotein A-Ib Neighboring gene septin 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. Fleck D, et al. J Neurosci, 2013 May 1. PMID 23637177, Free PMC Article
  2. Fishing for function--distinct roles of Bace1 and Bace2 in Zebrafish development. Walter J. J Neurochem, 2013 Nov. PMID 23527866
  3. Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. van Bebber F, et al. J Neurochem, 2013 Nov. PMID 23406323
  4. Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells. Lahiri DK, et al. J Mol Neurosci, 2006. PMID 16757811
  5. Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Park J, et al. J Neuroinflammation, 2023 Nov 9. PMID 37946213, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC77409

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta-secretase 1
Names
beta-site APP-cleaving enzyme 1
NP_991267.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205704.1 → NP_991267.1  beta-secretase 1

    See identical proteins and their annotated locations for NP_991267.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065973
    UniProtKB/TrEMBL
    Q6NZT7
    Conserved Domains (2) summary
    cd05473
    Location:77 → 443
    beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
    pfam00026
    Location:80 → 422
    Asp; Eukaryotic aspartyl protease

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    91018..97433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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