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tzn tenzing norgay [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40299, updated on 4-Jan-2025

Summary

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Official Symbol
tznprovided by FlyBase
Official Full Name
tenzing norgayprovided by FlyBase
Primary source
FLYBASE:FBgn0037024
Locus tag
Dmel_CG4365
See related
AllianceGenome:FB:FBgn0037024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4365; Dmel\CG4365
Summary
Predicted to enable hydroxyacylglutathione hydrolase activity. Involved in response to hypoxia. Predicted to be located in mitochondrial matrix. Is expressed in adult head; adult heart; germline cell; organism; and primordial germ cell. Orthologous to several human genes including HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See tzn in Genome Data Viewer
Location:
77E6-77E6; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20798645..20800081)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20791745..20793181)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43706 Neighboring gene uncharacterized protein Neighboring gene Spc105-related Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. Trinh K, et al. J Neurosci, 2008 Jan 9. PMID 18184789, Free PMC Article
  2. Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase. Muñoz-Soriano V, et al. J Mol Neurosci, 2012 Sep. PMID 22562816
  3. Intrakinetochore localization and essential functional domains of Drosophila Spc105. Schittenhelm RB, et al. EMBO J, 2009 Aug 19. PMID 19590494, Free PMC Article
  4. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Jha AR, et al. Mol Biol Evol, 2016 Feb. PMID 26576852, Free PMC Article
  5. Quantitative Proteomic Analyses of Molecular Mechanisms Associated with Cytoplasmic Incompatibility in Drosophila melanogaster Induced by Wolbachia. Yuan LL, et al. J Proteome Res, 2015 Sep 4. PMID 26220534

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydroxyacylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxyacylglutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyacylglutathione hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
Inferred from Electronic Annotation
more info
  
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tenzing norgay
Names
CG4365-PA
CG4365-PB
CG4365-PC
tzn-PA
tzn-PB
tzn-PC
NP_649258.1
NP_730568.1
NP_730569.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20798645..20800081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168874.2 → NP_730569.1  tenzing norgay, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730569.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7P8
    Related
    FBpp0077910
    Conserved Domains (3) summary
    PLN02469
    Location:13 → 270
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:187 → 267
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:16 → 186
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

  2. NM_168873.2 → NP_730568.1  tenzing norgay, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730568.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UUD4, Q8IPU3
    Related
    FBpp0077912
    Conserved Domains (3) summary
    PLN02469
    Location:90 → 347
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:264 → 344
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:93 → 263
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

  3. NM_141001.2 → NP_649258.1  tenzing norgay, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649258.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UUD4, Q9VPB3
    Related
    FBpp0077911, FBtr0078253
    Conserved Domains (3) summary
    PLN02469
    Location:47 → 304
    PLN02469; hydroxyacylglutathione hydrolase
    pfam16123
    Location:221 → 301
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cd07723
    Location:50 → 220
    hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IPU3 Q8IPU3
Q9I7P8 Q9I7P8
Q9VPB3 Q9VPB3

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