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Pcif1 Phosphorylated CTD-interacting factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40295, updated on 9-Dec-2024

Summary

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Official Symbol
Pcif1provided by FlyBase
Official Full Name
Phosphorylated CTD-interacting factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0037021
Locus tag
Dmel_CG11399
See related
AllianceGenome:FB:FBgn0037021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11399; Dmel\CG11399; dPcif1
Summary
Enables RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in wing disc dorsal/ventral pattern formation. Located in nucleus. Orthologous to human PCIF1 (phosphorylated CTD interacting factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Pcif1 in Genome Data Viewer
Location:
77E6-77E6; 3-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20780350..20786197, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20773450..20779297, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pitslre Neighboring gene Peroxin 16 Neighboring gene Peroxin 14 Neighboring gene antisense RNA:CR46484 Neighboring gene uncharacterized protein Neighboring gene Six4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The catalytic-dead Pcif1 regulates gene expression and fertility in Drosophila. Franco G, et al. RNA, 2023 May. PMID 36754578, Free PMC Article
  2. The Mammalian Cap-Specific m(6)Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues. Pandey RR, et al. Cell Rep, 2020 Aug 18. PMID 32814042
  3. Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. Fisher KH, et al. BMC Genomics, 2012 Sep 24. PMID 23006893, Free PMC Article
  4. A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Bejarano F, et al. Genetics, 2008 Jan. PMID 18202376, Free PMC Article
  5. A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability. Fisher KH, et al. J Cell Sci, 2018 Jul 6. PMID 29848658, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The catalytic-dead Pcif1 regulates gene expression and fertility in Drosophila.
    Title: The catalytic-dead Pcif1 regulates gene expression and fertility in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II C-terminal domain phosphoserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in wing disc dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphorylated CTD-interacting factor 1
Names
CG11399-PB
Pcif1-PB
phosphorylated C-terminal domain (CTD)-interacting factor 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20780350..20786197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140997.3 → NP_649254.2  phosphorylated CTD-interacting factor 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649254.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960B9, Q9VPB7
    Related
    FBpp0077935
    Conserved Domains (2) summary
    cd00201
    Location:143 → 170
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam12237
    Location:524 → 685
    PCIF1_WW; Phosphorylated CTD interacting factor 1 WW domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95T03 Q95T03
Q960B9 Q960B9
Q9VPB7 Q9VPB7

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