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Pex16 Peroxin 16 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40293, updated on 4-Jan-2025

Summary

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Official Symbol
Pex16provided by FlyBase
Official Full Name
Peroxin 16provided by FlyBase
Primary source
FLYBASE:FBgn0037019
Locus tag
Dmel_CG3947
See related
AllianceGenome:FB:FBgn0037019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3947; DmelPex16; Dmel\CG3947; pex16; PEX16
Summary
Involved in peroxisome organization; spermatogenesis; and very long-chain fatty acid catabolic process. Located in peroxisome. Is expressed in adult head and organism. Used to study Zellweger syndrome and peroxisome biogenesis disorder 8A. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 8B and peroxisome biogenesis disorder 8A. Orthologous to human PEX16 (peroxisomal biogenesis factor 16). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pex16 in Genome Data Viewer
Location:
77E6-77E6; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20776766..20778264, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20769866..20771364, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pitslre Neighboring gene Peroxin 14 Neighboring gene Phosphorylated CTD-interacting factor 1 Neighboring gene antisense RNA:CR46484 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse. Wangler MF, et al. PLoS Genet, 2017 Jun. PMID 28640802, Free PMC Article
  2. Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes. Nakayama M, et al. PLoS One, 2011. PMID 21826223, Free PMC Article
  3. The role of Peroxin 7 during Drosophila embryonic development. Pridie C, et al. Genome, 2021 Feb. PMID 32191843
  4. Recruitment of Peroxin 14 to lipid droplets affects lipid storage in Drosophila. Ueda K, et al. J Cell Sci, 2022 Apr 1. PMID 35274690
  5. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Chen H, et al. Hum Mol Genet, 2010 Feb 1. PMID 19933170

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in peroxisome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein import into peroxisome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in very long-chain fatty acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
peroxin 16
Names
CG3947-PA
Pex16-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20776766..20778264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140995.4 → NP_649252.1  peroxin 16 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649252.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VPB9
    Related
    FBpp0077936
    Conserved Domains (1) summary
    pfam08610
    Location:11 → 333
    Pex16; Peroxisomal membrane protein (Pex16)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPB9 Q9VPB9

Gene LinkOut

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