dstyk dual serine/threonine and tyrosine protein kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dstykprovided by ZNC
Official Full Name: dual serine/threonine and tyrosine protein kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040826-2
See related: Ensembl:ENSDARG00000000853 AllianceGenome:ZFIN:ZDB-GENE-040826-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ripk5; zgc:136421
Summary: Predicted to enable ATP binding activity and protein kinase activity. Involved in embryonic organ development. Acts upstream of or within notochord cell vacuolation and notochord morphogenesis. Predicted to be located in anchoring junction; apical plasma membrane; and basolateral plasma membrane. Predicted to be active in cytoplasm. Is expressed in head and notochord. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (473263..506956, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (435540..469246, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings reveal a key role of DSTYK in notochord vacuole biogenesis, notochord morphogenesis and spine development through mTORC1/TFEB pathway
Title: Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

G47599 (e-PCR)
- UniSTS:108373

G40318 (e-PCR)
- UniSTS:20891

Z4768 (e-PCR)
- UniSTS:12974

G39884 (e-PCR)
- UniSTS:20720

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to fibroblast growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within notochord cell vacuolation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dual serine/threonine and tyrosine protein kinase

Names: dusty PK; dusty protein kinase; receptor interacting protein kinase 5; receptor-interacting serine/threonine-protein kinase 5

NP_991190.2

EC 2.7.12.1

XP_005168327.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205627.2 → NP_991190.2 dual serine/threonine and tyrosine protein kinase

See identical proteins and their annotated locations for NP_991190.2

Status: PROVISIONAL

Source sequence(s)

AY429681

UniProtKB/Swiss-Prot

Q4VSN1

Related

ENSDARP00000067636.5, ENSDART00000067637.7

Conserved Domains (2) summary

smart00220
Location:587 → 831

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13975
Location:585 → 846

PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

473263..506956 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168270.5 → XP_005168327.1 dual serine/threonine and tyrosine protein kinase isoform X1

See identical proteins and their annotated locations for XP_005168327.1

UniProtKB/Swiss-Prot

Q0VFW4, Q4VSN1, Q5VJL5, Q6NWI9, Q6XUW8

Related

ENSDARP00000097423.3, ENSDART00000106645.6

Conserved Domains (2) summary

smart00220
Location:615 → 859

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13975
Location:613 → 874

PKc_Dusty; Catalytic domain of the Dual-specificity Protein Kinase, Dusty