cmpy crimpy [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cmpyprovided by FlyBase
Official Full Name: crimpyprovided by FlyBase
Primary source: FLYBASE:FBgn0037015
Locus tag: Dmel_CG13253
See related: AllianceGenome:FB:FBgn0037015
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13253; Cmpy; Dmel\CG13253
Summary: Enables BMP binding activity. Involved in negative regulation of BMP signaling pathway; neuromuscular junction development; and positive regulation of BMP signaling pathway. Located in dense core granule and extracellular space. Is expressed in RP neuron; embryonic brain; larval EL neuron; larval nervous system; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20712838..20719200, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20705938..20712300, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

propose that Gbb/Cmpy corelease from presynaptic terminals defines a neuronal protransmission signal
Title: Crimpy enables discrimination of presynaptic and postsynaptic pools of a BMP at the Drosophila neuromuscular junction.
Data demonstrate that crimpy (cmpy; CG13253) limits neuronal Gbb activity to permit appropriate regulation of neuromuscular junction growth.
Title: Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables BMP binding	IGI Inferred from Genetic Interaction more info	PubMed
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed