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hao1 hydroxyacid oxidase (glycolate oxidase) 1 [ Danio rerio (zebrafish) ]

Gene ID: 402827, updated on 4-Jan-2025

Summary

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Official Symbol
hao1provided by ZNC
Official Full Name
hydroxyacid oxidase (glycolate oxidase) 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-060519-2
See related
Ensembl:ENSDARG00000024160 AllianceGenome:ZFIN:ZDB-GENE-060519-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable (S)-2-hydroxy-acid oxidase activity and FMN binding activity. Orthologous to human HAO1 (hydroxyacid oxidase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See hao1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (4030493..4063581)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (3879456..3912544)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene phospholipase C beta 1 Neighboring gene thioredoxin-related transmembrane protein 4 Neighboring gene bone morphogenetic protein 2a Neighboring gene growth differentiation factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Toxicity assessment of atmospheric particulate matter in the Mediterranean and Black Seas open waters. Mesquita SR, et al. Sci Total Environ, 2016 Mar 1. PMID 26745302
  2. Toxic potential of organic constituents of submicron particulate matter (PM1) in an urban road site (Barcelona). Mesquita SR, et al. Environ Sci Pollut Res Int, 2017 Jun. PMID 28508335
  3. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Mesquita SR, et al. Environ Pollut, 2015 Nov. PMID 26298234
  4. Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine. Yang MJ, et al. Virulence, 2020 Dec. PMID 32316833, Free PMC Article
  5. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables (S)-2-hydroxy-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-Hydroxyacid oxidase 1
NP_001077011.1
XP_009291053.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083542.1 → NP_001077011.1  2-Hydroxyacid oxidase 1

    See identical proteins and their annotated locations for NP_001077011.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133873
    UniProtKB/TrEMBL
    A4FVH7
    Related
    ENSDARP00000126401.1, ENSDART00000151849.2
    Conserved Domains (2) summary
    cd02809
    Location:10 → 357
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:16 → 362
    FMN_dh; FMN-dependent dehydrogenase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    4030493..4063581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292778.4 → XP_009291053.1  2-Hydroxyacid oxidase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AIM9
    Conserved Domains (2) summary
    cd02809
    Location:10 → 304
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:16 → 309
    FMN_dh; FMN-dependent dehydrogenase
Nucleotide Protein
Heading Accession and Version

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