edem2 ER degradation enhancer, mannosidase alpha-like 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: edem2provided by ZNC
Official Full Name: ER degradation enhancer, mannosidase alpha-like 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-060519-1
See related: Ensembl:ENSDARG00000028448 AllianceGenome:ZFIN:ZDB-GENE-060519-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; mannoprotein catabolic process; and ubiquitin-dependent glycoprotein ERAD pathway. Predicted to act upstream of or within carbohydrate metabolic process; endoplasmic reticulum mannose trimming; and mannose trimming involved in glycoprotein ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (6950935..6982961, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (7016963..7048989, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endoplasmic reticulum mannose trimming	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mannose trimming involved in glycoprotein ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent glycoprotein ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ER degradation-enhancing alpha-mannosidase-like protein 2

NP_001292543.1

EC 3.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305614.1 → NP_001292543.1 ER degradation-enhancing alpha-mannosidase-like protein 2 precursor

Status: VALIDATED

Source sequence(s)

CU681838

UniProtKB/TrEMBL

A0A0R4IAP0, A0A8M1P1W0

Related

ENSDARP00000130442.1, ENSDART00000169965.3

Conserved Domains (1) summary

pfam01532
Location:42 → 479

Glyco_hydro_47; Glycosyl hydrolase family 47