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CG5199 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40265, updated on 4-Jan-2025

Summary

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Official Symbol
CG5199provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036994
Locus tag
Dmel_CG5199
See related
AllianceGenome:FB:FBgn0036994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CUT8; Dmel\CG5199
Summary
Predicted to enable proteasome binding activity. Involved in proteasome localization. Colocalizes with nuclear membrane. Is expressed in organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG5199 in Genome Data Viewer
Location:
77C3-77C3; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20450532..20452864, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20443632..20445964, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45176 Neighboring gene long non-coding RNA:CR43943 Neighboring gene 4-hydroxyphenylpyruvate dioxygenase Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U snoRNA host gene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. Takeda K, et al. Cell, 2005 Aug 12. PMID 16096059
  2. Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. Moshkin YM, et al. Mol Cell, 2009 Sep 24. PMID 19782028
  3. MicroRNA transgene overexpression complements deficiency-based modifier screens in Drosophila. Szuplewski S, et al. Genetics, 2012 Feb. PMID 22095085, Free PMC Article
  4. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article
  5. Transcription factor networks in Drosophila melanogaster. Rhee DY, et al. Cell Rep, 2014 Sep 25. PMID 25242320, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nuclear protein quality control by the ubiquitin-proteasome system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear protein quality control by the ubiquitin-proteasome system IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome localization IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5199-PA
CG5199-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20450532..20452864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275183.1 → NP_001262112.1  uncharacterized protein Dmel_CG5199, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262112.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXU1, Q9VPF1
    Conserved Domains (1) summary
    pfam08559
    Location:193 → 377
    Cut8; Cut8, nuclear proteasome tether protein

  2. NM_140970.4 → NP_649227.2  uncharacterized protein Dmel_CG5199, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649227.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXU1, Q9VPF1
    Related
    FBpp0077882
    Conserved Domains (1) summary
    pfam08559
    Location:193 → 377
    Cut8; Cut8, nuclear proteasome tether protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXU1 Q8SXU1
Q9VPF1 Q9VPF1

Gene LinkOut

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