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alphaSnap alpha Soluble NSF attachment protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40233, updated on 9-Dec-2024

Summary

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Official Symbol
alphaSnapprovided by FlyBase
Official Full Name
alpha Soluble NSF attachment proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0250791
Locus tag
Dmel_CG6625
See related
AllianceGenome:FB:FBgn0250791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
a-Snap; alpha-snap; alpha-Snap; alpha-SNAP; alphaSNAP; aSnap; CG6625; dalpha-SNAP; dalphaSNAP; Dmel\CG6625; dsnap; dSNAP; l(3)77ABa; l(3)77ABc; snap; Snap; SNAP; SnapII
Summary
Enables SNARE binding activity and soluble NSF attachment protein activity. Involved in several processes, including SNARE complex disassembly; chemical synaptic transmission; and imaginal disc-derived wing expansion. Located in cytoplasmic vesicle; membrane; and terminal bouton. Is expressed in several structures, including adult head; adult heart; brain; larval nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 107. Orthologous to human NAPA (NSF attachment protein alpha) and NAPB (NSF attachment protein beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See alphaSnap in Genome Data Viewer
Location:
77B3-77B3; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20313632..20316577)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20306732..20309677)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Squamous cell carcinoma-related oncogene 4 Neighboring gene uncharacterized protein Neighboring gene polo Neighboring gene antisense RNA:CR43875 Neighboring gene Serpin 77Ba Neighboring gene Serpin 77Bb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neurally expressed Drosophila genes encoding homologs of the NSF and SNAP secretory proteins. Ordway RW, et al. Proc Natl Acad Sci U S A, 1994 Jun 7. PMID 8202553, Free PMC Article
  2. An essential and NSF independent role for α-SNAP in store-operated calcium entry. Miao Y, et al. Elife, 2013 Jul 16. PMID 23878724, Free PMC Article
  3. Quantifying Glial-Glial Tiling Using Automated Image Analysis in Drosophila. Salazar G, et al. Front Cell Neurosci, 2022. PMID 35401121, Free PMC Article
  4. Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. Muller JM, et al. J Cell Biol, 2002 Jun 24. PMID 12070132, Free PMC Article
  5. Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila. Xu H, et al. Dev Biol, 2002 Nov 15. PMID 12435359

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that NSF and SNAP exhibit activity-dependent binding to each other within living presynaptic terminals as well as distinctive interactions and mobilities.
    Title: Activity-dependent interactions of NSF and SNAP at living synapses.
  2. Our results indicate that SNAP promotes neurotransmitter release and SNARE complex disassembly but inhibits secretion when present at high abundance relative to NSF
    Title: Genetic analysis of soluble N-ethylmaleimide-sensitive factor attachment protein function in Drosophila reveals positive and negative secretory roles.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables soluble NSF attachment protein activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables soluble NSF attachment protein activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables soluble NSF attachment protein activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables soluble NSF attachment protein activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SNARE complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SNARE complex disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing expansion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle priming NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha soluble NSF attachment protein
Names
CG6625-PA
alphaSnap-PA
lethal (3) 77ABa
lethal (3) 77ABc
soluble N-ethylmaleimide-sensitive factor attachment protein
soluble NSF attachment protein
soluble NSF-attachment protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20313632..20316577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079456.4 → NP_524180.1  alpha soluble NSF attachment protein [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524180.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23983, Q541G5
    Related
    FBpp0074609
    Conserved Domains (2) summary
    cd15832
    Location:7 → 284
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    pfam14938
    Location:7 → 284
    SNAP; Soluble NSF attachment protein, SNAP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23983.1 Q23983

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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