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CG42674 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40205, updated on 4-Jan-2025

Summary

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Official Symbol
CG42674provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0261556
Locus tag
Dmel_CG42674
See related
AllianceGenome:FB:FBgn0261556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13811; CG13812; CG32223; CG42348; CG7323; Dmel\CG42674
Old locus tag
Dmel_CG13811; Dmel_CG32223; Dmel_CG42348; Dmel_CG7323
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Is expressed in leg and organism. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to several human genes including PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG42674 in Genome Data Viewer
Location:
76F2-77A1; 3-47 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20149614..20198317, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20142714..20191417, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene gigas Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45942 Neighboring gene Snakeskin Neighboring gene uncharacterized protein Neighboring gene obstructor-F Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila. Yanagihashi Y, et al. J Cell Sci, 2012 Apr 15. PMID 22328496
  2. Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair. Nakamura M, et al. J Cell Biol, 2017 Dec 4. PMID 28923977, Free PMC Article
  3. Parallel and population-specific gene regulatory evolution in cold-adapted fly populations. Huang Y, et al. Genetics, 2021 Jul 14. PMID 33989401, Free PMC Article
  4. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. Greenberg L, et al. Mech Dev, 2011 Jan-Feb. PMID 20851182, Free PMC Article
  5. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42674-PA
CG42674-PB
CG42674-PC
CG42674-PD
CG42674-PE
CG42674-PF
CG42674-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20149614..20198317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275161.1 → NP_001262090.1  uncharacterized protein Dmel_CG42674, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262090.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFQ9
    Conserved Domains (2) summary
    cd13244
    Location:1057 → 1152
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    pfam00621
    Location:813 → 999
    RhoGEF; RhoGEF domain

  2. NM_001144514.3 → NP_001137986.1  uncharacterized protein Dmel_CG42674, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137986.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z086
    Conserved Domains (2) summary
    cd13244
    Location:1090 → 1185
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    pfam00621
    Location:846 → 1032
    RhoGEF; RhoGEF domain

  3. NM_001202208.2 → NP_001189137.1  uncharacterized protein Dmel_CG42674, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189137.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFQ9
    Conserved Domains (2) summary
    cd13244
    Location:1057 → 1152
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    pfam00621
    Location:813 → 999
    RhoGEF; RhoGEF domain

  4. NM_001144513.3 → NP_001137985.1  uncharacterized protein Dmel_CG42674, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137985.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z087
    Conserved Domains (2) summary
    cd13244
    Location:1090 → 1185
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    pfam00621
    Location:846 → 1032
    RhoGEF; RhoGEF domain

  5. NM_001144512.3 → NP_001137984.1  uncharacterized protein Dmel_CG42674, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137984.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z088
    Conserved Domains (2) summary
    cd13244
    Location:1271 → 1366
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    pfam00621
    Location:1027 → 1213
    RhoGEF; RhoGEF domain

  6. NM_140925.6 → NP_649182.4  uncharacterized protein Dmel_CG42674, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649182.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW85
    Conserved Domains (2) summary
    cd13244
    Location:1271 → 1366
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    pfam00621
    Location:1027 → 1213
    RhoGEF; RhoGEF domain

  7. NM_001275162.1 → NP_001262091.1  uncharacterized protein Dmel_CG42674, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262091.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG56
    Conserved Domains (2) summary
    cd13244
    Location:493 → 588
    PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
    pfam00621
    Location:249 → 435
    RhoGEF; RhoGEF domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z086 B7Z086
B7Z087 B7Z087
B7Z088 B7Z088
M9PFQ9 M9PFQ9
M9PG56 M9PG56
Q8SWY9 Q8SWY9
Q95R62 Q95R62
Q9VW85 Q9VW85

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