Ir76b Ionotropic receptor 76b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ir76bprovided by FlyBase
Official Full Name: Ionotropic receptor 76bprovided by FlyBase
Primary source: FLYBASE:FBgn0036937
Locus tag: Dmel_CG7385
See related: AllianceGenome:FB:FBgn0036937
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 76b; CG7385; CT22733; DmelIR76b; Dmel\CG7385; ir76b; IR76b; IR76B
Summary: Enables ionotropic salty taste receptor activity and sodium channel activity. Contributes to olfactory receptor activity. Involved in several processes, including cellular response to salt; detection of chemical stimulus involved in sensory perception of smell; and transmission of nerve impulse. Located in sensory dendrite. Part of receptor complex. Is expressed in several structures, including adult olfactory antennal lobe glomerulus; chemosensory neurons; ganglia; organism subdivision; and sense organ. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 76F1-76F1; 3-46 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20108484..20111534, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20101584..20104634, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IR76b-expressing neurons in Drosophila melanogaster are necessary for associative reward learning of an amino acid mixture.
Title: IR76b-expressing neurons in Drosophila melanogaster are necessary for associative reward learning of an amino acid mixture.
Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster.
Title: Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster.
Mutation in IR76b gene is associated with loss of appetitive behavioral responses to fatty acids.
Title: Molecular basis of fatty acid taste in Drosophila.
IR25a and IR76b are essential in sour gustatory receptor neurons of females for oviposition preference on acid-containing food.
Title: Ionotropic Receptors Mediate Drosophila Oviposition Preference through Sour Gustatory Receptor Neurons.
Our work extends the physiological implications of Ir76b from low-Na(+) attraction to high-Na(+) aversion, prompting further investigation of the physiological mechanisms that modulate two competing components of Na(+)-evoked gustation coded in heterogeneous Ir76b-positive GRNs.
Title: Ionotropic Receptor 76b Is Required for Gustatory Aversion to Excessive Na+ in Drosophila.
In the olfactory system IR76b mediates the long-range attraction to the odor.
Title: Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines.
this study demonstrated that a member of the newly discovered ionotropic glutamate receptor (IR) family, IR76b, functioned in the detection of low salt and was a Na(+) channel.
Title: The molecular basis for attractive salt-taste coding in Drosophila.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic salty taste receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	ISM Inferred from Sequence Model more info	PubMed
contributes_to olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to salt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to amino acid	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in salt aversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in sensory dendrite	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ionotropic receptor 76b

Names: CG7385-PA; Ir76b-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20108484..20111534 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140919.2 → NP_649176.1 ionotropic receptor 76b [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649176.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VW78

Related

FBpp0074638

Conserved Domains (1) summary

cl21456
Location:83 → 437

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily