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sNPF-R short neuropeptide F receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40195, updated on 4-Jan-2025

Summary

Official Symbol
sNPF-Rprovided by FlyBase
Official Full Name
short neuropeptide F receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0036934
Locus tag
Dmel_CG7395
See related
AllianceGenome:FB:FBgn0036934
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0131005.1; CG18639; CG7395; CG7395/CG18639; CT22771; Dmel\CG7395; Drm-NPFR76F; Drm-sNPF-R; GPCR60; NPFR76F; sNPF R; snpfr; sNPFR; sNPFR1
Summary
Enables short neuropeptide F receptor activity. Involved in several processes, including neuropeptide signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of feeding behavior. Located in plasma membrane. Is expressed in several structures, including ganglia; gut section; insulin secreting cell of pars intercerebralis; larval midline neurons; and sensory cluster. Human ortholog(s) of this gene implicated in Huntington's disease; hypertension; morbid obesity; and obesity. Orthologous to several human genes including PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See sNPF-R in Genome Data Viewer
Location:
76E2-76E4; 3-46 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20058511..20089007, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20051611..20082107, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene kugelei Neighboring gene uncharacterized protein Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene long non-coding RNA:CR44679 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables neuropeptide receptor activity ISM
Inferred from Sequence Model
more info
PubMed 
enables short neuropeptide F receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISM
Inferred from Sequence Model
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
short neuropeptide F receptor
Names
CG7395-PA
CG7395-PB
neuropeptide F-like receptor 76F
neuropeptide-Y-receptor
sNPF receptor
sNPF-R-PA
sNPF-R-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20058511..20089007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275157.1NP_001262086.1  short neuropeptide F receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262086.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW74, Q9VW75
    Conserved Domains (2) summary
    pfam00001
    Location:80393
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:75196
    7tm_4; Olfactory receptor
  2. NM_079452.3NP_524176.1  short neuropeptide F receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524176.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW74, Q9VW75
    Related
    FBpp0074640
    Conserved Domains (2) summary
    pfam00001
    Location:80393
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:75196
    7tm_4; Olfactory receptor