U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kug kugelei [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40191, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
kugprovided by FlyBase
Official Full Name
kugeleiprovided by FlyBase
Primary source
FLYBASE:FBgn0261574
Locus tag
Dmel_CG7749
See related
AllianceGenome:FB:FBgn0261574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cad76E; CG7749; CT23445; DCad76E; Dmel\CG7749; fat; Fat-like; fat2; Fat2; ft2; ftl; Ftl; Kug; RE-A
Summary
Enables cell adhesion molecule binding activity. Involved in several processes, including digestive tract morphogenesis; establishment of planar polarity of follicular epithelium; and oogenesis. Located in several cellular components, including basal plasma membrane; cell trailing edge; and focal adhesion. Is expressed in floor cell; main body follicle cell; nurse cell; roof cell; and spermatozoon. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Orthologous to several human genes including FAT1 (FAT atypical cadherin 1) and FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See kug in Genome Data Viewer
Location:
76E1-76E1; 3-46 cM
Exon count:
23
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20005301..20024607)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19998401..20017707)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid transaminase Neighboring gene Translocase of outer membrane 20 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene short neuropeptide F receptor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Fat-like cadherins in cell migration-leading from both the front and the back. Horne-Badovinac S. Curr Opin Cell Biol, 2017 Oct. PMID 28551508, Free PMC Article
  2. A Mutation in fat2 Uncouples Tissue Elongation from Global Tissue Rotation. Aurich F, et al. Cell Rep, 2016 Mar 22. PMID 26972006
  3. Scaling of internal organs during Drosophila embryonic development. Tiwari P, et al. Biophys J, 2021 Oct 5. PMID 34087212, Free PMC Article
  4. Modelling planar polarity of epithelia: the role of signal relay in collective cell polarization. Viktorinová I, et al. J R Soc Interface, 2011 Jul 6. PMID 21508014, Free PMC Article
  5. Geometric constraints alter cell arrangements within curved epithelial tissues. Rupprecht JF, et al. Mol Biol Cell, 2017 Dec 1. PMID 28978739, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells.
    Title: Fat2 polarizes Lar and Sema5c to coordinate the motility of collectively migrating epithelial cells.
  2. Data show that the atypical cadherin Fat2 directs and orchestrates transmission of the intracellular actomyosin asymmetry cue onto a tissue plane and facilitate epithelial rotation in the opposite direction.
    Title: Epithelial rotation is preceded by planar symmetry breaking of actomyosin and protects epithelial tissue from cell deformations.
  3. Fat2/Lar signaling mediates short-range communication between neighboring cells instead of transmitting long-range information across a tissue.
    Title: Fat2 and Lar Define a Basally Localized Planar Signaling System Controlling Collective Cell Migration.
  4. Concordant microtubule polarity, but not microtubule alignment, requires the atypical cadherin Fat2, which acts at an early stage to translate plus-end bias into coordinated actin-mediated collective cell migration.
    Title: Symmetry Breaking in an Edgeless Epithelium by Fat2-Regulated Microtubule Polarity.
  5. Planar polarized localization of Fat2 depends on intact microtubules.Microtubule polarity depends on the atypical cadherin Fat2.
    Title: Microtubule polarity predicts direction of egg chamber rotation in Drosophila.
  6. Fat2 is required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells
    Title: The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary.
  7. fat-like gene of Drosophila is involved in the formation of tubular organs
    Title: The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in centripetally migrating follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in establishment of planar polarity of follicular epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in growth of a germarium-derived egg chamber IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of innate immune response HMP PubMed 
involved_in protein localization to cell leading edge IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in salivary gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin-based cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell trailing edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
kugelei
Names
CG7749-PC
CG7749-PD
CG7749-PE
fat-like
fat2
kug-PC
kug-PD
kug-PE
kugel

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20005301..20024607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300197.1 → NP_001287126.1  kugelei, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCN4
    Conserved Domains (5) summary
    cd11304
    Location:3173 → 3269
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00179
    Location:4227 → 4262
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4195 → 4225
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3953 → 4077
    Laminin_G_2; Laminin G domain
    cl09101
    Location:309 → 390
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

  2. NM_140914.3 → NP_649171.3  kugelei, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649171.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCN4
    Conserved Domains (5) summary
    cd11304
    Location:3173 → 3269
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00179
    Location:4227 → 4262
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4195 → 4225
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3953 → 4077
    Laminin_G_2; Laminin G domain
    cl09101
    Location:309 → 390
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

  3. NM_001031967.2 → NP_001027138.2  kugelei, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027138.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V252, Q95S51, Q9VW71
    Conserved Domains (5) summary
    cd11304
    Location:3173 → 3269
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00179
    Location:4227 → 4262
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:4195 → 4225
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3953 → 4077
    Laminin_G_2; Laminin G domain
    cl09101
    Location:309 → 390
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VW71.3 Q9VW71
X2JCN4 X2JCN4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools