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kug - kugelei

Enables cell adhesion molecule binding activity. Involved in several processes, including digestive tract morphogenesis; establishment of planar polarity of follicular epithelium; and oogenesis. Located in several cellular components, including basal plasma membrane; cell trailing edge; and focal adhesion. Is expressed in floor cell; main body follicle cell; nurse cell; roof cell; and spermatozoon. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Orthologous to several human genes including FAT1 (FAT atypical cadherin 1) and FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa