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CG14182 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40181, updated on 9-Dec-2024

Summary

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Official Symbol
CG14182provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036922
Locus tag
Dmel_CG14182
See related
AllianceGenome:FB:FBgn0036922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14182
Summary
Predicted to be involved in negative regulation of smoothened signaling pathway. Predicted to be active in Golgi apparatus and ciliary membrane. Used to study chromosome 16p12.1 deletion syndrome. Orthologous to human MOSMO (modulator of smoothened). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG14182 in Genome Data Viewer
Location:
76D7-76D7; 3-46 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19978713..19979812, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19971813..19972912, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Adenylyl cyclase 76E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hale-bopp

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis. Pizzo L, et al. PLoS Genet, 2021 Apr. PMID 33819264, Free PMC Article
  2. Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. Yusuff T, et al. PLoS Genet, 2020 Jun. PMID 32579612, Free PMC Article
  3. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
  4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
  5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14182-PA
CG14182-PB
CG14182-PC
CG14182-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19978713..19979812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300194.1 → NP_001287123.1  uncharacterized protein Dmel_CG14182, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287123.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW61
    Conserved Domains (1) summary
    pfam18800
    Location:25 → 166
    Atthog; Attenuator of Hedgehog

  2. NM_001275154.2 → NP_001262083.1  uncharacterized protein Dmel_CG14182, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262083.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PIA7

  3. NM_140906.2 → NP_649163.1  uncharacterized protein Dmel_CG14182, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW61
    Related
    FBpp0074682
    Conserved Domains (1) summary
    pfam18800
    Location:25 → 166
    Atthog; Attenuator of Hedgehog

  4. NM_001275153.1 → NP_001262082.1  uncharacterized protein Dmel_CG14182, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262082.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW61
    Conserved Domains (1) summary
    pfam18800
    Location:25 → 166
    Atthog; Attenuator of Hedgehog
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PIA7 M9PIA7
Q9VW61 Q9VW61

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