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RhoGDI RhoGDI [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40179, updated on 9-Dec-2024

Summary

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Official Symbol
RhoGDIprovided by FlyBase
Official Full Name
RhoGDIprovided by FlyBase
Primary source
FLYBASE:FBgn0036921
Locus tag
Dmel_CG7823
See related
AllianceGenome:FB:FBgn0036921
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7823; Dmel\CG7823
Summary
Predicted to enable Rho GDP-dissociation inhibitor activity. Predicted to be involved in Rho protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol and membrane. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and mesoderm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha); ARHGDIB (Rho GDP dissociation inhibitor beta); and ARHGDIG (Rho GDP dissociation inhibitor gamma). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See RhoGDI in Genome Data Viewer
Location:
76D5-76D5; 3-46 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19928743..19932930)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19921843..19926030)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Grasp65 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45678 Neighboring gene uncharacterized protein Neighboring gene Adenylyl cyclase 76E Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Pebble/Rho1/Anillin pathway controls polyploidization and axonal wrapping activity in the glial cells of the Drosophila eye. Tavares L, et al. Dev Biol, 2021 May. PMID 33581137
  2. Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Magie CR, et al. Development, 2002 Aug. PMID 12135916
  3. Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier. Koehler S, et al. Kidney Int, 2022 Apr. PMID 34929254
  4. Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc. Noyes A, et al. G3 (Bethesda), 2011 Nov. PMID 22384357, Free PMC Article
  5. Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair. Nakamura M, et al. J Cell Biol, 2017 Dec 4. PMID 28923977, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Rho GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Rho GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RhoGDI
Names
CG7823-PA
CG7823-PB
RhoGDI-PA
RhoGDI-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19928743..19932930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140905.3 → NP_649162.1  RhoGDI, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW59
    Related
    FBpp0074665
    Conserved Domains (1) summary
    pfam02115
    Location:14 → 199
    Rho_GDI; RHO protein GDP dissociation inhibitor

  2. NM_001275151.1 → NP_001262080.1  RhoGDI, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262080.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VW59
    Conserved Domains (1) summary
    pfam02115
    Location:14 → 199
    Rho_GDI; RHO protein GDP dissociation inhibitor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VW59 Q9VW59

Gene LinkOut

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