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Kap-alpha1 karyopherin alpha1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40160, updated on 9-Dec-2024

Summary

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Official Symbol
Kap-alpha1provided by FlyBase
Official Full Name
karyopherin alpha1provided by FlyBase
Primary source
FLYBASE:FBgn0024889
Locus tag
Dmel_CG8548
See related
AllianceGenome:FB:FBgn0024889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alphaKap1; anon-WO0118547.276; CG8548; Dalpha1; Dmalpha1; Dmel\CG8548; imp alpha1; Imp alpha1; imp-alpha1; Imp-alpha1; impalpha1; Impalpha1; IMPalpha1; Kap alpha1; Kapalpha1S1; Kpna1
Summary
Enables nuclear localization sequence binding activity. Involved in NLS-bearing protein import into nucleus and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in adult head and organism. Orthologous to several human genes including KPNA1 (karyopherin subunit alpha 1) and KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Kap-alpha1 in Genome Data Viewer
Location:
76C6-76C6; 3-46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19807232..19810398)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19800332..19803498)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain-containing 58 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 305a1 Neighboring gene cycle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatial and temporal control of expression with light-gated LOV-LexA. Ribeiro IMA, et al. G3 (Bethesda), 2022 Sep 30. PMID 35876796, Free PMC Article
  2. Drosophila Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche. Heaney J, et al. Cells, 2024 Mar 12. PMID 38534338, Free PMC Article
  3. Novel nicotinic action of the sulfoximine insecticide sulfoxaflor. Watson GB, et al. Insect Biochem Mol Biol, 2011 Jul. PMID 21296156
  4. Patterns of importin-alpha expression during Drosophila spermatogenesis. Giarrè M, et al. J Struct Biol, 2002 Oct-Dec. PMID 12490175
  5. The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors. Beckmann JF, et al. Elife, 2019 Nov 27. PMID 31774393, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study identified a potential nuclear localization signal at the N-terminal end of Yorkie as well as a critical role for Importin alpha 1 in Yorkie nuclear import.
    Title: Importin α1 Mediates Yorkie Nuclear Import via an N-terminal Non-canonical Nuclear Localization Signal.
  2. This is supported by attenuated interaction of IMPa1 with TIM carrying a mutation previously shown to prevent nuclear entry of TIM and PER.
    Title: Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.
  3. Drosophila alpha1 performs paralog-specific activities that are essential for gametogenesis and regulation of subcellular alpha1 localization may affect cell fate decisions.
    Title: Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis.
  4. each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
    Title: Patterns of importin-alpha expression during Drosophila spermatogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NLS-bearing protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
karyopherin alpha1
Names
CG8548-PA
Kap-alpha1-PA
importin alpha1
importin-alpha1
karyopherin alpha 1
karyopherin-alpha1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19807232..19810398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079443.2 → NP_524167.1  karyopherin alpha1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524167.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76521, Q9U1H6
    Related
    FBpp0074650
    Conserved Domains (5) summary
    COG5064
    Location:1 → 543
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:131 → 252
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:3 → 116
    IBB; Importin beta binding domain
    pfam16186
    Location:473 → 517
    Arm_3; Atypical Arm repeat
    sd00043
    Location:133 → 165
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76521 O76521
Q5U119 Q5U119
Q8MZI6 Q8MZI6
Q9U1H6 Q9U1H6

Gene LinkOut

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