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CRIP3 cysteine rich protein 3 [ Homo sapiens (human) ]

Gene ID: 401262, updated on 27-Nov-2024

Summary

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Official Symbol
CRIP3provided by HGNC
Official Full Name
cysteine rich protein 3provided by HGNC
Primary source
HGNC:HGNC:17751
See related
Ensembl:ENSG00000146215 AllianceGenome:HGNC:17751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLP; CRP-3; TLP-A; h6LIMo
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within T cell proliferation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver (RPKM 2.8), heart (RPKM 2.6) and 13 other tissues See more
Orthologs
mouse all
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Genomic context

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See CRIP3 in Genome Data Viewer
Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43305472..43308826, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43134412..43137765, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43273210..43276564, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tau tubulin kinase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43239819-43240068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43245015-43245670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43245671-43246325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43254414-43255266 Neighboring gene Sharpr-MPRA regulatory region 10500 Neighboring gene uncharacterized LOC124901319 Neighboring gene solute carrier family 22 member 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43275224-43276081 Neighboring gene ribosomal protein L12 pseudogene 47 Neighboring gene ribosomal protein L34 pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis. Suzuki H, et al. Sci Rep, 2019 Mar 19. PMID 30890736, Free PMC Article
  2. The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern. Casrouge A, et al. Microbes Infect, 2004 Oct. PMID 15380775, Free PMC Article
  3. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis.
    Title: TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: ZNF318

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cysteine-rich protein 3
Names
chromosome 6 LIM domain only protein
thymus LIM protein TLP-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366068.1 → NP_001352997.1  cysteine-rich protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL583834
    Conserved Domains (2) summary
    cd09476
    Location:5 → 58
    LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
    cd09477
    Location:80 → 133
    LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

  2. NM_206922.3 → NP_996805.2  cysteine-rich protein 3 isoform 1

    See identical proteins and their annotated locations for NP_996805.2

    Status: VALIDATED

    Source sequence(s)
    AA813350, AI042209, AY555741, CN282994, CR976447
    Consensus CDS
    CCDS4894.2
    UniProtKB/Swiss-Prot
    A2A436, Q5T043, Q6Q6R4, Q6Q6R5, Q6Q6R6, Q6Q6R7
    Related
    ENSP00000361650.3, ENST00000372569.8
    Conserved Domains (2) summary
    cd09476
    Location:5 → 58
    LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
    cd09477
    Location:124 → 177
    LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43305472..43308826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43134412..43137765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Q6R5.2 GenPept UniProtKB/Swiss-Prot:Q6Q6R5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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