pip pipe [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pipprovided by FlyBase
Official Full Name: pipeprovided by FlyBase
Primary source: FLYBASE:FBgn0003089
Locus tag: Dmel_CG9614
See related: AllianceGenome:FB:FBgn0003089
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9614; Dmel\CG9614; l(3)76BDp; PIP2; Pipe; pipe-ST2
Summary: Enables endopeptidase activator activity and sulfotransferase activity. Involved in several processes, including Toll receptor ligand protein activation cascade; dorsal/ventral axis specification; and embryonic pattern specification. Located in Golgi apparatus; chromosome; and nucleus. Is expressed in several structures, including adult brain; follicle cell; gland; gonad; and gut section. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human UST (uronyl 2-sulfotransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 76A5-76A6; 3-45 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19298623..19337609, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19291723..19330709, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings show that Mirror (Mirr), a homeodomain transcription factor induced by EGFR signaling in DA follicle cells, directly represses pipe expression by binding to a conserved element in the pipe regulatory region
Title: Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila.
Pipe modifies proteins that are incorporated in the ventral eggshell and activate Toll signaling which in turn initiates embryonic dorsoventral patterning.
Title: Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila.
promotes 6-O- and/or N-sulfation of heparan sulfate but is not required for heparan sulfate 2-O-sulfation
Title: Distinct heparan sulfate compositions in wild-type and pipe-mutant eggshell matrix.
no requirement for nudel to be expressed in ventral, pipe-expressing follicle cells
Title: No requirement for localized Nudel protein expression in Drosophila embryonic axis determination.
observation suggests a mechanism in which the sulfated target of Pipe promotes a productive interaction between Snake and Easter, perhaps by facilitating conformational changes in a complex containing the two proteins
Title: Pipe-dependent ventral processing of Easter by Snake is the defining step in Drosophila embryo DV axis formation.
Snake activation is cascade-dependent but pipe-independent. Snake's activation of Easter is the first spatially regulated step in the dorsoventral protease cascade.
Title: Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.
Sulfation of eggshell components by Pipe defines dorsal-ventral polarity in the Drosophila embryo.
Title: Sulfation of eggshell components by Pipe defines dorsal-ventral polarity in the Drosophila embryo.
Data indicate that differences in functional specificity, and presumably enzymatic specificity, are associated with several of the Pipe isoforms.
Title: Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe.
Pipe induces ventral cell fates in the embryo via activation of the Spatzle/Toll pathway.
Title: Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila.
Pipe acts as a sulfotransferase
Title: Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables chondroitin sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables endopeptidase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables heparan sulfate sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll receptor ligand protein activation cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	NAS Non-traceable Author Statement more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pipe

Names: CG9614-PA; CG9614-PC; CG9614-PD; CG9614-PF; CG9614-PG; CG9614-PH; CG9614-PI; CG9614-PJ; CG9614-PK; CG9614-PL; CG9614-PN; pip-PA; pip-PC; pip-PD; pip-PF; pip-PG; pip-PH; pip-PI; pip-PJ; pip-PK; pip-PL; pip-PN