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Gbs-76A Glycogen binding subunit 76A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40102, updated on 9-Dec-2024

Summary

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Official Symbol
Gbs-76Aprovided by FlyBase
Official Full Name
Glycogen binding subunit 76Aprovided by FlyBase
Primary source
FLYBASE:FBgn0036862
Locus tag
Dmel_CG9619
See related
AllianceGenome:FB:FBgn0036862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
149039_at; CG9619; Dmel\CG9619; GBS-76A
Summary
Enables protein phosphatase 1 binding activity. Predicted to be involved in negative regulation of glycogen catabolic process and positive regulation of glycogen biosynthetic process. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A) and PPP1R3D (protein phosphatase 1 regulatory subunit 3D). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Gbs-76A in Genome Data Viewer
Location:
76A3-76A5; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19281364..19292766, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19274464..19285866, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46048 Neighboring gene falten Neighboring gene pipe

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of the glycogen binding subunit CG9238/Gbs-70E of protein phosphatase 1 in Drosophila melanogaster. Kerekes É, et al. Insect Biochem Mol Biol, 2014 Jun. PMID 24727027
  2. Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster. Kristensen TN, et al. Genetics, 2006 Jul. PMID 16624914, Free PMC Article
  3. Dissection of Complex, Fitness-Related Traits in Multiple Drosophila Mapping Populations Offers Insight into the Genetic Control of Stress Resistance. Everman ER, et al. Genetics, 2019 Apr. PMID 30760490, Free PMC Article
  4. The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells. Landskron L, et al. Elife, 2018 Mar 27. PMID 29580384, Free PMC Article
  5. Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. Bennett D, et al. J Mol Biol, 2006 Nov 24. PMID 17007873

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of glycogen catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glycogen binding subunit 76A
Names
CG9619-PA
CG9619-PB
CG9619-PC
CG9619-PD
Gbs-76A-PA
Gbs-76A-PB
Gbs-76A-PC
Gbs-76A-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19281364..19292766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300189.1 → NP_001287118.1  glycogen binding subunit 76A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287118.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGL1, Q8T0I8, Q9VVY3
    UniProtKB/TrEMBL
    M9PCY7
    Conserved Domains (1) summary
    pfam03370
    Location:526 → 631
    CBM_21; Carbohydrate/starch-binding module (family 21)

  2. NM_001275115.1 → NP_001262044.1  glycogen binding subunit 76A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262044.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGL1, Q8T0I8, Q9VVY3
    UniProtKB/TrEMBL
    M9PCY7
    Conserved Domains (1) summary
    pfam03370
    Location:526 → 631
    CBM_21; Carbohydrate/starch-binding module (family 21)

  3. NM_001275114.1 → NP_001262043.1  glycogen binding subunit 76A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262043.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGL1, Q8T0I8, Q9VVY3
    UniProtKB/TrEMBL
    M9PCY7
    Conserved Domains (1) summary
    pfam03370
    Location:526 → 631
    CBM_21; Carbohydrate/starch-binding module (family 21)

  4. NM_140847.2 → NP_649104.1  glycogen binding subunit 76A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649104.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGL1, Q8T0I8, Q9VVY3
    UniProtKB/TrEMBL
    M9PCY7
    Related
    FBpp0074781
    Conserved Domains (1) summary
    pfam03370
    Location:526 → 631
    CBM_21; Carbohydrate/starch-binding module (family 21)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCY7 M9PCY7
Q9VVY3.1 Q9VVY3

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