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rept reptin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40092, updated on 9-Dec-2024

Summary

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Official Symbol
reptprovided by FlyBase
Official Full Name
reptinprovided by FlyBase
Primary source
FLYBASE:FBgn0040075
Locus tag
Dmel_CG9750
See related
AllianceGenome:FB:FBgn0040075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0142479.1; CG9750; Dmel\CG9750; drep; dRep; dReptin; dRUVBL2; l(3)06945; psg10; Q9V3K3_DROME; rep; REP; Rept; REPT; Reptin; Tip48; Tip48/Reptin
Summary
Enables transcription corepressor activity. Involved in several processes, including autophagic cell death; chromatin remodeling; and negative regulation of canonical Wnt signaling pathway. Located in nucleus. Part of Ino80 complex; NuA4 histone acetyltransferase complex; and R2TP complex. Is expressed in several structures, including embryonic/larval midgut primordium; head epidermis primordium; mesoderm; sensory nervous system primordium; and visceral mesoderm derivative. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See rept in Genome Data Viewer
Location:
76A3-76A3; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19255340..19257111)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19248440..19250211)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46216 Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene antisense RNA:CR45210 Neighboring gene nessy Neighboring gene Blocked early in transport 1 Neighboring gene Max

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Bellosta P, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16087886, Free PMC Article
  2. Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes. Huen J, et al. Biochem Cell Biol, 2010 Feb. PMID 20130677
  3. A Simple Cross-Linking/Mass Spectrometry Workflow for Studying System-wide Protein Interactions. Götze M, et al. Anal Chem, 2019 Aug 6. PMID 31283178
  4. Strongly Truncated Dnaaf4 Plays a Conserved Role in Drosophila Ciliary Dynein Assembly as Part of an R2TP-Like Co-Chaperone Complex With Dnaaf6. Lennon J, et al. Front Genet, 2022. PMID 35873488, Free PMC Article
  5. Spaghetti, a homolog of human RPAP3 (RNA polymerase II-associated protein 3), determines the fate of germline stem cells in Drosophila ovary. Chen D, et al. Cell Biol Int, 2018 Jul. PMID 29110400

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WAC promotes the interaction between TTT and Pontin/Reptin in an energy-dependent manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag interaction
    Title: WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
  2. The enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output.
    Title: Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control.
  3. Rept and pontin have conserved their ability to bind to Myc during evolution
    Title: Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.
  4. Drosophila Reptin participates in epigenetic processes leading to a repressive chromatin state.
    Title: Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagic cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in box C/D snoRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IC
Inferred by Curator
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ecdysone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of R2TP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of R2TP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
reptin
Names
CG9750-PA
CG9750-PB
CG9750-PC
dReptin
rept-PA
rept-PB
rept-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19255340..19257111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079432.3 → NP_524156.1  reptin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524156.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3K3
    UniProtKB/TrEMBL
    M9PFN1
    Related
    FBpp0074756
    Conserved Domains (3) summary
    cd00009
    Location:267 → 358
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam06068
    Location:17 → 408
    TIP49; TIP49 C-terminus
    cl21455
    Location:69 → 113
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001300184.1 → NP_001287113.1  reptin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287113.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3K3
    UniProtKB/TrEMBL
    M9PFN1
    Conserved Domains (3) summary
    cd00009
    Location:267 → 358
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam06068
    Location:17 → 408
    TIP49; TIP49 C-terminus
    cl21455
    Location:69 → 113
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001275111.1 → NP_001262040.1  reptin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262040.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3K3
    UniProtKB/TrEMBL
    M9PFN1
    Conserved Domains (3) summary
    cd00009
    Location:267 → 358
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam06068
    Location:17 → 408
    TIP49; TIP49 C-terminus
    cl21455
    Location:69 → 113
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFN1 M9PFN1
Q9V3K3.1 Q9V3K3

Gene LinkOut

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