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CNPYb Canopy b [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40084, updated on 4-Jan-2025

Summary

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Official Symbol
CNPYbprovided by FlyBase
Official Full Name
Canopy bprovided by FlyBase
Primary source
FLYBASE:FBgn0036847
Locus tag
Dmel_CG11577
See related
AllianceGenome:FB:FBgn0036847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.323; CG11577; Dmel\CG11577
Summary
Enables protein-folding chaperone binding activity. Involved in chaperone-mediated protein folding. Located in endomembrane system. Is expressed in organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 60. Orthologous to several human genes including CNPY4 (canopy FGF signaling regulator 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CNPYb in Genome Data Viewer
Location:
75F7-75F7; 3-45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19094890..19096217, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19087990..19089317, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45386 Neighboring gene Misexpression suppressor of ras 6 Neighboring gene NAD(P)HX dehydratase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila canopy b is a cochaperone of glycoprotein 93. Morales C, et al. J Biol Chem, 2017 Apr 21. PMID 28275054, Free PMC Article
  2. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
  3. A single-cell atlas and lineage analysis of the adult Drosophila ovary. Rust K, et al. Nat Commun, 2020 Nov 6. PMID 33159074, Free PMC Article
  4. Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila. Vesala L, et al. BMC Biol, 2024 Mar 13. PMID 38475850, Free PMC Article
  5. Mapping organelle proteins and protein complexes in Drosophila melanogaster. Tan DJ, et al. J Proteome Res, 2009 Jun. PMID 19317464

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
canopy b
Names
CG11577-PA
CNPYb-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19094890..19096217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140832.4 → NP_649089.2  canopy b [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649089.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95S24, Q9VVW7
    Related
    FBpp0074801
    Conserved Domains (1) summary
    pfam11938
    Location:35 → 184
    DUF3456; TLR4 regulator and MIR-interacting MSAP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95S24 Q95S24
Q9VVW7 Q9VVW7

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