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SmydA-2 SET and MYND domain containing, arthropod-specific, member 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40075, updated on 4-Jan-2025

Summary

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Official Symbol
SmydA-2provided by FlyBase
Official Full Name
SET and MYND domain containing, arthropod-specific, member 2provided by FlyBase
Primary source
FLYBASE:FBgn0036839
Locus tag
Dmel_CG18136
See related
AllianceGenome:FB:FBgn0036839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18136; Dmel\CG18136
Summary
Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to be active in nucleus. Is expressed in adult head; larval muscle system; and larval somatic muscle cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See SmydA-2 in Genome Data Viewer
Location:
75F2-75F2; 3-45 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19000985..19003252, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18994085..18996352, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene naked cuticle Neighboring gene long non-coding RNA:CR45940 Neighboring gene Accessory gland protein 76A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of the feedback antagonist naked cuticle by Wingless signaling. Chang JL, et al. Dev Biol, 2008 Sep 15. PMID 18585374, Free PMC Article
  2. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
  3. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
  4. DEAF-1 function is essential for the early embryonic development of Drosophila. Veraksa A, et al. Genesis, 2002 Jun. PMID 12112874
  5. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-lysine N-methyltransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SET and MYND domain containing, arthropod-specific, member 2
Names
CG18136-PA
SmydA-2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19000985..19003252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140827.3 → NP_649084.1  SET and MYND domain containing, arthropod-specific, member 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5WLS5, Q9VVV8
    Related
    FBpp0074807
    Conserved Domains (2) summary
    smart00317
    Location:246 → 291
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam01753
    Location:9 → 46
    zf-MYND; MYND finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVV8 Q9VVV8

Gene LinkOut

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