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CG6839 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40067, updated on 4-Jan-2025

Summary

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Official Symbol
CG6839provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036831
Locus tag
Dmel_CG6839
See related
AllianceGenome:FB:FBgn0036831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6839
Summary
Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6839 in Genome Data Viewer
Location:
75E5-75E6; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18917581..18919259)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18910681..18912359)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 1b Neighboring gene pre-mRNA processing factor 6 Neighboring gene Cytochrome c oxidase subunit 6A-like 2 Neighboring gene Ionotropic receptor 75d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of hunger-driven gene expression in the Drosophila melanogaster larval central nervous system. Ryuda M, et al. Zoolog Sci, 2008 Jul. PMID 18828662
  2. Temporal Exposure to Bt Insecticide Causes Oxidative Stress in Larval Midgut Tissue. Muita BK, et al. Toxins (Basel), 2023 May 7. PMID 37235357, Free PMC Article
  3. Drosophila p53 directs nonapoptotic programs in postmitotic tissue. Kurtz P, et al. Mol Biol Cell, 2019 May 15. PMID 30892991, Free PMC Article
  4. Seizure suppression by gain-of-function escargot mutations. Hekmat-Scafe DS, et al. Genetics, 2005 Mar. PMID 15654097, Free PMC Article
  5. The gut microbiome participates in transgenerational inheritance of low-temperature responses in Drosophila melanogaster. Zare A, et al. FEBS Lett, 2018 Dec. PMID 30372516, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6839-PA
NP_649076.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18917581..18919259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140819.2 → NP_649076.1  uncharacterized protein Dmel_CG6839 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVU9
    Related
    FBpp0074836
    Conserved Domains (1) summary
    cd00091
    Location:170 → 420
    NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TI9 Q95TI9
Q9VVU9 Q9VVU9

Gene LinkOut

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