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COX6AL2 Cytochrome c oxidase subunit 6A-like 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40066, updated on 9-Dec-2024

Summary

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Official Symbol
COX6AL2provided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 6A-like 2provided by FlyBase
Primary source
FLYBASE:FBgn0036830
Locus tag
Dmel_CG14077
See related
AllianceGenome:FB:FBgn0036830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14077; Dmel\CG14077; VIa
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 18. Orthologous to human COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See COX6AL2 in Genome Data Viewer
Location:
75E5-75E5; 3-45 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18908260..18914150, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18901360..18907250, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 1b Neighboring gene pre-mRNA processing factor 6 Neighboring gene Ionotropic receptor 75d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Compartment specific mitochondrial dysfunction in Drosophila knock-in model of ALS reversed by altered gene expression of OXPHOS subunits and pro-fission factor Drp1. Nemtsova Y, et al. Mol Cell Neurosci, 2023 Jun. PMID 36868541, Free PMC Article
  2. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Szuplewski S, et al. Genetics, 2001 Aug. PMID 11514451, Free PMC Article
  3. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817
  4. Recent Advances in Drosophila Models of Charcot-Marie-Tooth Disease. Kitani-Morii F, et al. Int J Mol Sci, 2020 Oct 8. PMID 33049996, Free PMC Article
  5. Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models. Bussmann J, et al. Curr Opin Genet Dev, 2017 Jun. PMID 28213160

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 6A-like 2
Names
CG14077-PB
CG14077-PC
COX6AL2-PB
COX6AL2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18908260..18914150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140818.3 → NP_649075.1  cytochrome c oxidase subunit 6A-like 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649075.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVU8
    Related
    FBpp0289099
    Conserved Domains (1) summary
    cd00925
    Location:146 → 229
    Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_001259899.1 → NP_001246828.1  cytochrome c oxidase subunit 6A-like 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246828.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVU8
    Conserved Domains (1) summary
    cd00925
    Location:146 → 229
    Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVU8 Q9VVU8

Gene LinkOut

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