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NijB Ninjurin B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40057, updated on 4-Jan-2025

Summary

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Official Symbol
NijBprovided by FlyBase
Official Full Name
Ninjurin Bprovided by FlyBase
Primary source
FLYBASE:FBgn0036822
Locus tag
Dmel_CG11637
See related
AllianceGenome:FB:FBgn0036822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11637; Dmel\CG11637; nijB; NINJ-B
Summary
Involved in cytolysis. Predicted to be located in membrane. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See NijB in Genome Data Viewer
Location:
75E4-75E4; 3-45 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18892383..18893278)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18885483..18886378)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene UDP-glucose-glycoprotein glucosyltransferase Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NINJ1 mediates plasma membrane rupture during lytic cell death. Kayagaki N, et al. Nature, 2021 Mar. PMID 33472215
  2. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Zhang S, et al. Genes Dev, 2006 Jul 15. PMID 16815999, Free PMC Article
  3. Antagonistic regulation of apoptosis and differentiation by the Cut transcription factor represents a tumor-suppressing mechanism in Drosophila. Zhai Z, et al. PLoS Genet, 2012. PMID 22438831, Free PMC Article
  4. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article
  5. Single-cell RNA sequencing identifies novel cell types in Drosophila blood. Fu Y, et al. J Genet Genomics, 2020 Apr 20. PMID 32487456, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cytolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tissue regeneration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ninjurin B
Names
CG11637-PA
NijB-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18892383..18893278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140811.2 → NP_649068.1  ninjurin B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649068.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V5W5, Q9VVT9
    Related
    FBpp0074832
    Conserved Domains (1) summary
    pfam04923
    Location:75 → 172
    Ninjurin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVT9.1 Q9VVT9

Gene LinkOut

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