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CG14073 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40046, updated on 9-Dec-2024

Summary

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Official Symbol
CG14073provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036814
Locus tag
Dmel_CG14073
See related
AllianceGenome:FB:FBgn0036814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14073; Nirvana
Summary
Predicted to enable transcription corepressor activity. Involved in wing disc dorsal/ventral pattern formation. Predicted to be active in nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome; dental caries; eye disease (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including BCORL1 (BCL6 corepressor like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG14073 in Genome Data Viewer
Location:
75E1-75E1; 3-45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18802265..18820675, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18795365..18813775, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45938 Neighboring gene ftz transcription factor 1 Neighboring gene long non-coding RNA:CR45939 Neighboring gene HP1-HOAP-interacting protein Neighboring gene Catalase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microarray-based capture of novel expressed cell type-specific transfrags (CoNECT) to annotate tissue-specific transcription in Drosophila melanogaster. Hong X, et al. G3 (Bethesda), 2012 Aug. PMID 22908036, Free PMC Article
  2. A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Bejarano F, et al. Genetics, 2008 Jan. PMID 18202376, Free PMC Article
  3. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. Pal S, et al. J Biol Chem, 2007 Mar 23. PMID 17227774
  4. The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Beckstead RB, et al. Genome Biol, 2005. PMID 16356271, Free PMC Article
  5. Variant Polycomb complexes in Drosophila consistent with ancient functional diversity. Kang H, et al. Sci Adv, 2022 Sep 9. PMID 36070387, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wing disc dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14073-PB
CG14073-PC
nirvana

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18802265..18820675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275093.1 → NP_001262022.1  uncharacterized protein Dmel_CG14073, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262022.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQT4
    Conserved Domains (4) summary
    cd00204
    Location:1697 → 1807
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14259
    Location:2016 → 2129
    PUFD_like; PCGF Ub-like fold discriminator and related domains
    pfam12796
    Location:1702 → 1790
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1697 → 1728
    ANK; ANK repeat [structural motif]

  2. NM_140803.2 → NP_649060.1  uncharacterized protein Dmel_CG14073, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQT4
    Related
    FBpp0074851
    Conserved Domains (4) summary
    cd00204
    Location:1697 → 1807
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14259
    Location:2016 → 2129
    PUFD_like; PCGF Ub-like fold discriminator and related domains
    pfam12796
    Location:1702 → 1790
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1697 → 1728
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQT4 Q8IQT4
Q8MT12 Q8MT12

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