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MED11 Mediator complex subunit 11 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40042, updated on 9-Dec-2024

Summary

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Official Symbol
MED11provided by FlyBase
Official Full Name
Mediator complex subunit 11provided by FlyBase
Primary source
FLYBASE:FBgn0036811
Locus tag
Dmel_CG6884
See related
AllianceGenome:FB:FBgn0036811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.71; BcDNA:GH01072; CG6884; dMED21; Dmel\CG6884; med11; Med11; Med21
Summary
Predicted to enable transcription coactivator activity. Predicted to contribute to transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Orthologous to human MED11 (mediator complex subunit 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See MED11 in Genome Data Viewer
Location:
75D8-75D8; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18745856..18746623)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18738956..18739723)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43985 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45938 Neighboring gene nufip Neighboring gene ftz transcription factor 1 Neighboring gene Autophagy-related 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity. Park J, et al. Elife, 2019 Jun 21. PMID 31223115, Free PMC Article
  2. The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex. Conrad T, et al. Dev Cell, 2012 Mar 13. PMID 22421046
  3. Differential Requirements for Mediator Complex Subunits in Drosophila melanogaster Host Defense Against Fungal and Bacterial Pathogens. Huang C, et al. Front Immunol, 2020. PMID 33746938, Free PMC Article
  4. MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Kim TW, et al. Proc Natl Acad Sci U S A, 2004 Aug 17. PMID 15297616, Free PMC Article
  5. A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia. Azpurua J, et al. PLoS Genet, 2021 Nov. PMID 34723963, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
contributes_to transcription coregulator activity IC
Inferred by Curator
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator complex subunit 11
Names
CG6884-PA
MED11-PA
RNA poll II transcription mediator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18745856..18746623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140800.3 → NP_649057.1  mediator complex subunit 11 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649057.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVS4
    Related
    FBpp0074821
    Conserved Domains (1) summary
    pfam10280
    Location:5 → 110
    Med11; Mediator complex protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVS4.1 Q9VVS4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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