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Dic4 Dicarboxylate carrier 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40039, updated on 4-Jan-2025

Summary

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Official Symbol
Dic4provided by FlyBase
Official Full Name
Dicarboxylate carrier 4provided by FlyBase
Primary source
FLYBASE:FBgn0036808
Locus tag
Dmel_CG18363
See related
AllianceGenome:FB:FBgn0036808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18363; DmDic4p; Dmel\CG18363
Summary
Predicted to enable antiporter activity; sulfate transmembrane transporter activity; and thiosulfate transmembrane transporter activity. Predicted to be involved in phosphate ion transmembrane transport; sulfate transmembrane transport; and thiosulfate transport. Is active in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Dic4 in Genome Data Viewer
Location:
75D6-75D6; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18696402..18698412, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18689502..18691512, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43987 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44674 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel subfamily of mitochondrial dicarboxylate carriers from Drosophila melanogaster: biochemical and computational studies. Iacopetta D, et al. Biochim Biophys Acta, 2011 Mar. PMID 21130726
  2. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
  3. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
  4. Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Junion G, et al. Genes Dev, 2007 Dec 1. PMID 18056427, Free PMC Article
  5. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables dicarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in dicarboxylic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dicarboxylate carrier 4
Names
CG18363-PA
CG18363-PB
CG18363-PC
Dic4-PA
Dic4-PB
Dic4-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18696402..18698412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275092.1 → NP_001262021.1  dicarboxylate carrier 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262021.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVS1
    Conserved Domains (2) summary
    PTZ00169
    Location:26 → 288
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:104 → 201
    Mito_carr; Mitochondrial carrier protein

  2. NM_001275091.2 → NP_001262020.1  dicarboxylate carrier 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262020.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFM0
    Conserved Domains (1) summary
    pfam00153
    Location:26 → 100
    Mito_carr; Mitochondrial carrier protein

  3. NM_140797.3 → NP_649054.1  dicarboxylate carrier 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649054.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVS1
    Related
    FBpp0074857
    Conserved Domains (2) summary
    PTZ00169
    Location:26 → 288
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:104 → 201
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFM0 M9PFM0
Q9VVS1 Q9VVS1

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