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anchor anchor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39965, updated on 4-Jan-2025

Summary

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Official Symbol
anchorprovided by FlyBase
Official Full Name
anchorprovided by FlyBase
Primary source
FLYBASE:FBgn0036741
Locus tag
Dmel_CG7510
See related
AllianceGenome:FB:FBgn0036741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-74EFa; CG7510; Dmel\CG7510
Summary
Involved in imaginal disc-derived wing vein morphogenesis and negative regulation of BMP signaling pathway. Predicted to be located in membrane. Is expressed in adult head; amnioserosa; embryonic/larval fat body; organism; and yolk nucleus. Orthologous to human GPR155 (G protein-coupled receptor 155). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See anchor in Genome Data Viewer
Location:
74E2-74E3; 3-45 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17621824..17630971)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17614924..17624071)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ecdysone-induced protein 74EF Neighboring gene small Cajal body-specific RNA : MeU4-A65 Neighboring gene Vacuolar protein sorting 60 Neighboring gene long non-coding RNA:CR44566 Neighboring gene long non-coding RNA:CR44567

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Anchor maintains gut homeostasis by restricting the JNK and Notch pathways in Drosophila. Wang J, et al. J Insect Physiol, 2021 Oct. PMID 34496279
  2. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Burtis KC, et al. Cell, 1990 Apr 6. PMID 2107982
  3. Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster. Lyman RF, et al. Proc Biol Sci, 2023 Apr 12. PMID 37040806, Free PMC Article
  4. Anchor negatively regulates BMP signalling to control Drosophila wing development. Wang XC, et al. Eur J Cell Biol, 2018 May. PMID 29735293
  5. Mapping Quantitative Trait Loci Underlying Circadian Light Sensitivity in Drosophila. Adewoye AB, et al. J Biol Rhythms, 2017 Oct. PMID 28990443

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CG7510 (Anchor) negatively regulates BMP signalling during wing development and vein formation.
    Title: Anchor negatively regulates BMP signalling to control Drosophila wing development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
anchor
Names
CG7510-PA
CG7510-PB
anchor-PA
anchor-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17621824..17630971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275066.1 → NP_001261995.1  anchor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFK5
    Conserved Domains (2) summary
    cd04443
    Location:871 → 953
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:53 → 387
    Mem_trans; Membrane transport protein

  2. NM_140741.3 → NP_648998.2  anchor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648998.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRD7, Q9VVJ0
    Related
    FBpp0074947
    Conserved Domains (2) summary
    cd04443
    Location:863 → 945
    DEP_GPR155; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in GPR155-like proteins. GRP155-like proteins, also known as PGR22, contain an N-terminal permease domain, a central transmembrane region and a C-terminal DEP domain. They are orphan receptors of the ...
    cl22894
    Location:53 → 387
    Mem_trans; Membrane transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFK5 M9PFK5
Q95T60 Q95T60
Q9VVJ0 Q9VVJ0

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