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Jon74E Jonah 74E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39959, updated on 4-Jan-2025

Summary

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Official Symbol
Jon74Eprovided by FlyBase
Official Full Name
Jonah 74Eprovided by FlyBase
Primary source
FLYBASE:FBgn0023197
Locus tag
Dmel_CG6298
See related
AllianceGenome:FB:FBgn0023197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6298; CT19724; Dmel\CG6298; SP85
Summary
Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Jon74E in Genome Data Viewer
Location:
74D3-74D4; 3-45 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17548077..17549127, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17539839..17542227, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Enhancer of decapping 3 Neighboring gene long non-coding RNA:CR45165 Neighboring gene Nedd4 Neighboring gene uncharacterized protein Neighboring gene Cyclin T

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Burtis KC, et al. Cell, 1990 Apr 6. PMID 2107982
  2. Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo. Keleman K, et al. Nat Neurosci, 2005 Feb. PMID 15657595
  3. The Jonah genes: a new multigene family in Drosophila melanogaster. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416610
  4. Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure. Rollmann SM, et al. Genetics, 2008 Jul. PMID 18562639, Free PMC Article
  5. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
jonah 74E
Names
CG6298-PC
Jon74E-PC
NP_001189126.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17548077..17549127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202197.1 → NP_001189126.2  jonah 74E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QP19, M9MS20
    Conserved Domains (1) summary
    smart00020
    Location:31 → 262
    Tryp_SPc; Trypsin-like serine protease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MS20 M9MS20

Gene LinkOut

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