U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sec3 Secretory 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39940, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Sec3provided by FlyBase
Official Full Name
Secretory 3provided by FlyBase
Primary source
FLYBASE:FBgn0266669
Locus tag
Dmel_CG3885
See related
AllianceGenome:FB:FBgn0266669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3885; Dmel\CG3885; sec3
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Part of exocyst. Is expressed in adult head. Orthologous to human EXOC1 (exocyst complex component 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sec3 in Genome Data Viewer
Location:
74B2-74B3; 3-45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17421787..17425217, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17414887..17418317, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bloated tubules Neighboring gene long non-coding RNA:noe Neighboring gene Cytochrome c oxidase subunit 7B Neighboring gene RNA polymerase III subunit G

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Exocyst Component Sec3 Controls Egg Chamber Development Through Notch During Drosophila Oogenesis. Wan P, et al. Front Physiol, 2019. PMID 30984026, Free PMC Article
  2. Guidance receptor promotes the asymmetric distribution of exocyst and recycling endosome during collective cell migration. Wan P, et al. Development, 2013 Dec. PMID 24198275
  3. PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. Gass MM, et al. Cell Mol Life Sci, 2022 Apr 18. PMID 35437696, Free PMC Article
  4. Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium. Chaudhary V, et al. PLoS Genet, 2019 Sep. PMID 31527874, Free PMC Article
  5. The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ. Kang CJ, et al. Mol Cell Neurosci, 2024 Mar. PMID 38086519

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
secretory 3
Names
CG3885-PA
Sec3 ortholog
Sec3-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17421787..17425217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140719.4 → NP_648976.2  secretory 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648976.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95R79, Q9VVG4
    UniProtKB/TrEMBL
    V5P0Q7
    Related
    FBpp0074993
    Conserved Domains (2) summary
    cd14683
    Location:9 → 126
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:200 → 866
    Sec3_C; Exocyst complex component Sec3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVG4.2 Q9VVG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous