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CG6652 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39905, updated on 9-Dec-2024

Summary

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Official Symbol
CG6652provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036687
Locus tag
Dmel_CG6652
See related
AllianceGenome:FB:FBgn0036687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6652
Summary
Predicted to be involved in intraciliary transport. Located in axoneme. Is expressed in adult head. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 5. Orthologous to several human genes including LCA5L (lebercilin LCA5 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG6652 in Genome Data Viewer
Location:
73E4-73E4; 3-45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17020348..17022856, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17013448..17015956, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antennal protein 10 Neighboring gene Fermitin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila. Lapart JA, et al. Elife, 2019 Dec 10. PMID 31821146, Free PMC Article
  2. Cep131-Cep162 and Cby-Fam92 complexes cooperatively maintain Cep290 at the basal body and contribute to ciliogenesis initiation. Wu Z, et al. PLoS Biol, 2024 Mar. PMID 38442096, Free PMC Article
  3. CEP290 is essential for the initiation of ciliary transition zone assembly. Wu Z, et al. PLoS Biol, 2020 Dec. PMID 33370260, Free PMC Article
  4. Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells. Vieillard J, et al. J Cell Biol, 2016 Sep 26. PMID 27646273, Free PMC Article
  5. The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia. Xiang W, et al. Sci Rep, 2022 Aug 3. PMID 35922464, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG6652-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17020348..17022856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140689.4 → NP_648946.3  uncharacterized protein Dmel_CG6652 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648946.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TY6, Q9VVD0
    Related
    FBpp0075051
    Conserved Domains (3) summary
    pfam15619
    Location:82 → 257
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cd16269
    Location:239 → 250
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:151 → 252
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVD0 Q9VVD0

Gene LinkOut

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