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CG3764 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39902, updated on 9-Dec-2024

Summary

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Official Symbol
CG3764provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036684
Locus tag
Dmel_CG3764
See related
AllianceGenome:FB:FBgn0036684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG3764
Summary
Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1) and FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG3764 in Genome Data Viewer
Location:
73E2-73E4; 3-45 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16994717..17012565, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16987817..17005665, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 73D Neighboring gene Odorant-binding protein 73a Neighboring gene Oxoglutarate dehydrogenase Neighboring gene Ephexin Neighboring gene mir-2500 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Kadener S, et al. Genes Dev, 2007 Jul 1. PMID 17578907, Free PMC Article
  2. A genetic toolkit for tagging intronic MiMIC containing genes. Nagarkar-Jaiswal S, et al. Elife, 2015 Jun 23. PMID 26102525, Free PMC Article
  3. Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1. Zhang T, et al. J Cell Sci, 2015 Aug 1. PMID 26092939, Free PMC Article
  4. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489
  5. Systems genetics of complex traits in Drosophila melanogaster. Ayroles JF, et al. Nat Genet, 2009 Mar. PMID 19234471, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c16999682-16999637 mobile_element_type = transposon:INE-1{}3912

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG3764-PA
CG3764-PB
CG3764-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16994717..17012565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275048.1 → NP_001261977.1  uncharacterized protein Dmel_CG3764, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261977.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3CTN7, Q8T0L7
    Conserved Domains (3) summary
    pfam14636
    Location:101 → 222
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:461 → 692
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:1269 → 1460
    FNIP_C; Folliculin-interacting protein C-terminus

  2. NM_001275049.1 → NP_001261978.1  uncharacterized protein Dmel_CG3764, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261978.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0L7, Q9VVC7
    Conserved Domains (3) summary
    pfam14636
    Location:17 → 138
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:377 → 608
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:1185 → 1376
    FNIP_C; Folliculin-interacting protein C-terminus

  3. NM_140686.4 → NP_648943.2  uncharacterized protein Dmel_CG3764, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648943.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0L7, Q9VVC7
    Related
    FBpp0075057
    Conserved Domains (3) summary
    pfam14636
    Location:17 → 138
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:377 → 608
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:1185 → 1376
    FNIP_C; Folliculin-interacting protein C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E3CTN7 E3CTN7
Q8T0L7 Q8T0L7
Q9VVC7 Q9VVC7

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