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sina - seven in absentia

Enables ubiquitin protein ligase activity. Involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of R7 cell differentiation; and sevenless signaling pathway. Located in cytosol and nucleus. Part of ubiquitin ligase complex. Is expressed in several structures, including embryonic/larval fat body; epithelium; gut section; imaginal disc; and sensory organ cell. Orthologous to several human genes including SIAH1 (siah E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa