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zetaCOP Coat Protein (coatomer) zeta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39862, updated on 4-Jan-2025

Summary

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Official Symbol
zetaCOPprovided by FlyBase
Official Full Name
Coat Protein (coatomer) zetaprovided by FlyBase
Primary source
FLYBASE:FBgn0040512
Locus tag
Dmel_CG3948
See related
AllianceGenome:FB:FBgn0040512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3948; copz1; CT13124; Dmel\CG3948; zeta-Cop; zeta-COP; zetaCop
Summary
Involved in regulation of lipid storage. Predicted to be part of COPI vesicle coat. Is expressed in several structures, including embryonic epidermis; embryonic proventriculus; embryonic/larval salivary gland; presumptive embryonic salivary gland; and salivary gland body primordium. Orthologous to several human genes including COPZ1 (COPI coat complex subunit zeta 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See zetaCOP in Genome Data Viewer
Location:
73B5-73B6; 3-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16671664..16673555, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16664764..16666655, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46033 Neighboring gene G protein alpha subunit f Neighboring gene long non-coding RNA:CR45241 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lasp Neighboring gene long non-coding RNA:CR45179

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An orchestrated program regulating secretory pathway genes and cargos by the transmembrane transcription factor CREB-H. Barbosa S, et al. Traffic, 2013 Apr. PMID 23279168, Free PMC Article
  2. Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1. Martin M, et al. Mol Biol Cell, 2005 Sep. PMID 15975902, Free PMC Article
  3. COPI activity coupled with fatty acid biosynthesis is required for viral replication. Cherry S, et al. PLoS Pathog, 2006 Oct. PMID 17040126, Free PMC Article
  4. Golgi-dependent reactivation and regeneration of Drosophila quiescent neural stem cells. Gujar MR, et al. Dev Cell, 2023 Oct 9. PMID 37567172
  5. Expression of COPI components during development of Drosophila melanogaster. Grieder NC, et al. Gene Expr Patterns, 2005 Dec. PMID 16169286

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IEA
Inferred from Electronic Annotation
more info
  
part_of COPI vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
coat protein (coatomer) zeta
Names
CG3948-PA
CG3948-PB
CG3948-PC
COPI zeta subunit
zetaCOP-PA
zetaCOP-PB
zetaCOP-PC
zetacop

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16671664..16673555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168679.2 → NP_730188.1  coat protein (coatomer) zeta, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2NUJ2, Q8IQP2
    Related
    FBpp0075110
    Conserved Domains (1) summary
    cl02092
    Location:1 → 138
    Clat_adaptor_s; Clathrin adaptor complex small chain

  2. NM_140653.3 → NP_648910.1  coat protein (coatomer) zeta, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648910.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2NUJ2, Q9NKX6, Q9VV89
    Related
    FBpp0075111
    Conserved Domains (1) summary
    cd14829
    Location:10 → 142
    Zeta-COP; zeta subunit of the F-COPI complex

  3. NM_168680.2 → NP_730189.1  coat protein (coatomer) zeta, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2NUJ2, Q8IQP1
    Related
    FBpp0075112
    Conserved Domains (1) summary
    cl02092
    Location:9 → 149
    Clat_adaptor_s; Clathrin adaptor complex small chain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IQP1 Q8IQP1
Q8IQP2 Q8IQP2
Q9VV89 Q9VV89

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