U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Su(P) Suppressor of ref(2)P sterility [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39856, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Su(P)provided by FlyBase
Official Full Name
Suppressor of ref(2)P sterilityprovided by FlyBase
Primary source
FLYBASE:FBgn0004465
Locus tag
Dmel_CG4086
See related
AllianceGenome:FB:FBgn0004465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4086; Dmel\CG4086
Summary
Predicted to enable prostaglandin-E synthase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; larval muscle cell; and mesoderm. Orthologous to human PTGES2 (prostaglandin E synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Su(P) in Genome Data Viewer
Location:
73B1-73B1; 3-44 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16610662..16612199, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16603762..16605299, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Artemis Neighboring gene uncharacterized protein Neighboring gene Proteasome beta6 subunit Neighboring gene antisense RNA:CR45865 Neighboring gene uncharacterized protein Neighboring gene Mo25

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo study of the PB1 domain of Ref(2)P. Carré-Mlouka A, et al. Genetics, 2007 May. PMID 17409092, Free PMC Article
  2. Long disordered regions of the C-terminal domain of Abelson tyrosine kinase have specific and additive functions in regulation and axon localization. Cheong HSJ, et al. PLoS One, 2017. PMID 29232713, Free PMC Article
  3. Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration. Mellentine SQ, et al. Front Cell Dev Biol, 2023. PMID 38283991, Free PMC Article
  4. Genetic and molecular features of Su(P), a gene that interacts with ref(2)P in male fertility of Drosophila melanogaster. Bichon A, et al. Mol Genet Genomics, 2001 Apr. PMID 11361347
  5. A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. Scarpati M, et al. PLoS One, 2019. PMID 30753230, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables prostaglandin-E synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin-E synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables prostaglandin-E synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
suppressor of ref(2)P sterility
Names
CG4086-PA
Su(P)-PA
NP_524116.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16610662..16612199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079392.4 → NP_524116.2  suppressor of ref(2)P sterility [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524116.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U5V9, Q9V420
    Related
    FBpp0075118
    Conserved Domains (2) summary
    cd03197
    Location:247 → 400
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    cd03040
    Location:124 → 201
    GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77287 O77287
Q9U5V9 Q9U5V9
Q9V420 Q9V420

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous