U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG43373 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39835, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CG43373provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0263131
Locus tag
Dmel_CG43373
See related
AllianceGenome:FB:FBgn0263131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC; CG12436; CG32158; CG42513; dADCY5; Dmel\CG43373
Old locus tag
Dmel_CG12436; Dmel_CG32158; Dmel_CG42513
Summary
Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and cAMP biosynthetic process. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to several human genes including ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG43373 in Genome Data Viewer
Location:
73A3-73A5; 3-44 cM
Exon count:
32
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16491838..16543370, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16484938..16536470, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene doublesex cognate 73A Neighboring gene argos Neighboring gene uncharacterized protein Neighboring gene scarlet Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses. Yoon W, et al. Commun Biol, 2022 Aug 25. PMID 36008531, Free PMC Article
  2. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. González J, et al. PLoS Genet, 2010 Apr 8. PMID 20386746, Free PMC Article
  3. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378
  4. Refining a steroidogenic model: an analysis of RNA-seq datasets from insect prothoracic glands. Moulos P, et al. BMC Genomics, 2018 Jul 13. PMID 30005604, Free PMC Article
  5. Molecular Basis for Cephalic Mechanosensitivity of Drosophila Larvae. Zhang Z, et al. Neurosci Bull, 2020 Sep. PMID 32761438, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: c16494489-16494049 mobile_element_type = transposon:jockey{}1013

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG43373-PB
CG43373-PC
NP_001097622.2
NP_730173.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16491838..16543370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168670.4 → NP_730173.3  uncharacterized protein Dmel_CG43373, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730173.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV68
    Conserved Domains (4) summary
    smart00044
    Location:686 → 881
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:722 → 895
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:949 → 1005
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:523 → 720
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  2. NM_001104152.4 → NP_001097622.2  uncharacterized protein Dmel_CG43373, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097622.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNU1
    Conserved Domains (4) summary
    smart00044
    Location:686 → 881
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:722 → 895
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:949 → 1005
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:523 → 720
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNU1 A8JNU1
Q9VV68 Q9VV68

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous