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pitx3.L paired like homeodomain 3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398183, updated on 4-Jan-2025

Summary

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Official Symbol
pitx3.L
Official Full Name
paired like homeodomain 3 L homeolog
Primary source
Xenbase:XB-GENE-486166
Locus tag
XELAEV_18034876mg
See related
EnsemblRapid:ENSXLAG00005030489 AllianceGenome:Xenbase:XB-GENE-486166
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pitx3; xPitx3; XPitx-3; pitx3.S
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 1; cataract; cataract 11 multiple types; and cataract 9 multiple types. Orthologous to human PITX3 (paired like homeodomain 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pitx3.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
4
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (41587535..41635262, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (39108775..39156559, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 L homeolog Neighboring gene cDNA sequence BC014685 L homeolog Neighboring gene golgi brefeldin A resistant guanine nucleotide exchange factor 1 L homeolog Neighboring gene ELOVL fatty acid elongase 3 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xpitx3: a member of the Rieg/Pitx gene family expressed during pituitary and lens formation in Xenopus laevis. Pommereit D, et al. Mech Dev, 2001 Apr. PMID 11287205
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
paired like homeodomain 3 L homeolog
Names
homeodomain transcription factor Pitx-3
paired-like homeodomain 3 S homeolog
paired-like homeodomain transcription factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088554.1 → NP_001082023.1  paired like homeodomain 3 L homeolog

    Status: PROVISIONAL

    Source sequence(s)
    AF297713
    UniProtKB/TrEMBL
    A0A974CC62, A0A974HBJ0, B7ZRH8
    Related
    ENSXLAP00005091185.1, ENSXLAT00005092865.1
    Conserved Domains (2) summary
    pfam00046
    Location:64 → 117
    Homeobox; Homeobox domain
    pfam03826
    Location:250 → 267
    OAR; OAR domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    41587535..41635262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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