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CG4842 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39817, updated on 4-Jan-2025

Summary

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Official Symbol
CG4842provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036620
Locus tag
Dmel_CG4842
See related
AllianceGenome:FB:FBgn0036620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4842
Summary
Predicted to enable alcohol dehydrogenase (NAD+) activity. Predicted to be involved in alcohol metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG4842 in Genome Data Viewer
Location:
72E2-72E3; 3-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16368389..16369518)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16361489..16362618)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 72Eb Neighboring gene Cuticular protein 72Ec Neighboring gene uncharacterized protein Neighboring gene roquin Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Hernández-Tobías A, et al. Chem Biol Interact, 2011 May 30. PMID 21329681
  2. The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. Lim DH, et al. FEBS Lett, 2011 Oct 3. PMID 21889502
  3. Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes. Chatterjee D, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25472843, Free PMC Article
  4. Identification of neural outgrowth genes using genome-wide RNAi. Sepp KJ, et al. PLoS Genet, 2008 Jul 4. PMID 18604272, Free PMC Article
  5. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alcohol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in alcohol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4842-PA
NP_648885.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16368389..16369518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140628.3 → NP_648885.1  uncharacterized protein Dmel_CG4842 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648885.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV47
    Related
    FBpp0075142
    Conserved Domains (2) summary
    pfam00106
    Location:6 → 194
    adh_short; short chain dehydrogenase
    cl21454
    Location:6 → 247
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VV47 Q9VV47

Gene LinkOut

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