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Strump Strumpellin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39766, updated on 4-Jan-2025

Summary

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Official Symbol
Strumpprovided by FlyBase
Official Full Name
Strumpellinprovided by FlyBase
Primary source
FLYBASE:FBgn0036571
Locus tag
Dmel_CG12272
See related
AllianceGenome:FB:FBgn0036571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12272; Dmel\CG12272; p118; strump
Summary
Involved in nuclear envelope budding and positive regulation of cell adhesion. Located in nucleoplasm. Part of WASH complex. Colocalizes with nuclear envelope. Is expressed in adult head. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 1 and hereditary spastic paraplegia 8. Orthologous to human WASHC5 (WASH complex subunit 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Strump in Genome Data Viewer
Location:
72D8-72D8; 3-44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16122002..16126052)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16115102..16119152)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Zinc-finger protein at 72D Neighboring gene TBP-associated factor 4 Neighboring gene Phosphoglucose mutase 1 Neighboring gene Signal sequence receptor beta Neighboring gene TRAPP subunit 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary conservation of the WASH complex, an actin polymerization machine involved in endosomal fission. Derivery E, et al. Commun Integr Biol, 2010 May. PMID 20714399, Free PMC Article
  2. Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis. Verboon JM, et al. J Cell Sci, 2018 Apr 13. PMID 29549166, Free PMC Article
  3. Drosophila WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization. Nagel BM, et al. J Cell Sci, 2017 Jan 15. PMID 27884932
  4. WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Jia D, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498093, Free PMC Article
  5. Rho family GTPase functions in Drosophila epithelial wound repair. Verboon JM, et al. Small GTPases, 2015. PMID 25862164, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear envelope budding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of WASH complex IEA
Inferred from Electronic Annotation
more info
  
part_of WASH complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
strumpellin
Names
CG12272-PA
CG12272-PB
CG12272-PC
Strump-PA
Strump-PB
Strump-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16122002..16126052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169983.2 → NP_001163454.1  strumpellin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0AVW2, D3DMJ6, Q9VUY8
    Conserved Domains (1) summary
    pfam10266
    Location:22 → 1132
    Strumpellin; Hereditary spastic paraplegia protein strumpellin

  2. NM_140583.4 → NP_648840.1  strumpellin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648840.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0AVW2, D3DMJ6, Q9VUY8
    Related
    FBpp0075208
    Conserved Domains (1) summary
    pfam10266
    Location:22 → 1132
    Strumpellin; Hereditary spastic paraplegia protein strumpellin

  3. NM_001275000.1 → NP_001261929.1  strumpellin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261929.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCR4
    Conserved Domains (1) summary
    pfam10266
    Location:22 → 1108
    Strumpellin; Hereditary spastic paraplegia protein strumpellin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCR4 M9PCR4
Q9VUY8.1 Q9VUY8

Gene LinkOut

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