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sff sugar-free frosting [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39732, updated on 4-Jan-2025

Summary

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Official Symbol
sffprovided by FlyBase
Official Full Name
sugar-free frostingprovided by FlyBase
Primary source
FLYBASE:FBgn0036544
Locus tag
Dmel_CG6114
See related
AllianceGenome:FB:FBgn0036544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BRSK1; CG6114; Dmel\CG6114
Summary
Predicted to enable tau-protein kinase activity. Involved in neuromuscular junction development and protein N-linked glycosylation. Predicted to be located in cytoplasm and nucleus. Is expressed in adult head; larval peripheral nervous system; larval ventral nerve cord; and ventral midline of embryo. Orthologous to human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See sff in Genome Data Viewer
Location:
72A4-72B1; 3-43 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15900156..15924861, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15893256..15917961, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pH-sensitive chloride channel 1 Neighboring gene long non-coding RNA:CR44051 Neighboring gene long non-coding RNA:CR44050 Neighboring gene Protein kinase, cAMP-dependent, catalytic subunit 3 Neighboring gene GXIVsPLA2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of protein N-glycosylation in neural transmission. Scott H, et al. Glycobiology, 2014 May. PMID 24643084, Free PMC Article
  2. Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. Baas S, et al. Development, 2011 Feb. PMID 21205799, Free PMC Article
  3. Drosophila LKB1 is required for the assembly of the polarized actin structure that allows spermatid individualization. Couderc JL, et al. PLoS One, 2017. PMID 28767695, Free PMC Article
  4. The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination. Crump JG, et al. Neuron, 2001 Jan. PMID 11182085
  5. Synaptogenesis: insights from worm and fly. Jin Y. Curr Opin Neurobiol, 2002 Feb. PMID 11861167

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sugar-free frosting
Names
CG6114-PA
CG6114-PB
CG6114-PC
SNF1-related
sff-PA
sff-PB
sff-PC
NP_001261901.1
NP_001261902.1
NP_648814.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15900156..15924861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274972.1 → NP_001261901.1  sugar-free frosting, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261901.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFS3, Q95T82
    Conserved Domains (3) summary
    smart00220
    Location:18 → 269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:298 → 350
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:16 → 269
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

  2. NM_001274973.1 → NP_001261902.1  sugar-free frosting, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261902.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFM1, Q95T82
    Conserved Domains (3) summary
    smart00220
    Location:18 → 269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:298 → 350
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:16 → 269
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

  3. NM_140557.5 → NP_648814.3  sugar-free frosting, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648814.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95T82, Q9VUV4
    Related
    FBpp0088511
    Conserved Domains (3) summary
    smart00220
    Location:18 → 269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:298 → 350
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:16 → 269
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFM1 M9PFM1
M9PFS3 M9PFS3
Q95T82 Q95T82
Q9VUV4 Q9VUV4

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