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MYD88 MYD88 innate immune signal transduction adaptor [ Sus scrofa (pig) ]

Gene ID: 396646, updated on 17-Aug-2024

Summary

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Official Symbol
MYD88provided by VGNC
Official Full Name
MYD88 innate immune signal transduction adaptorprovided by VGNC
Primary source
VGNC:VGNC:109468
See related
Ensembl:ENSSSCG00000011251
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in spleen (RPKM 48.5), lung (RPKM 41.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See MYD88 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (22976951..22979568)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (25181100..25183718)

Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene phospholipase C delta 1 Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene oxidative stress responsive kinase 1 Neighboring gene solute carrier family 22 member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and functional characterization of porcine MyD88 essential for TLR signaling. Tohno M, et al. Cell Mol Immunol, 2007 Oct. PMID 17976317
  2. Toll-like receptor 7 and MyD88 knockdown by lentivirus-mediated RNA interference to porcine dendritic cell subsets. Alves MP, et al. Gene Ther, 2007 May. PMID 17330086
  3. TLR2/MyD88/NF-κB signalling pathway regulates IL-8 production in porcine alveolar macrophages infected with porcine circovirus 2. Qin Y, et al. J Gen Virol, 2016 Feb. PMID 26581603
  4. Toll-like receptors 2 and 4 in pigs' kidneys early after autotransplantation procedure. Caban A, et al. Transplant Proc, 2014 Oct. PMID 25380861
  5. Identification of key immune mediators regulating T helper 1 responses in swine. Dawson HD, et al. Vet Immunol Immunopathol, 2004 Jul. PMID 15183000

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88/NF-kappaB signalling pathway.
    Title: TLR2/MyD88/NF-κB signalling pathway regulates IL-8 production in porcine alveolar macrophages infected with porcine circovirus 2.
  2. At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88.
    Title: Toll-like receptors 2 and 4 in pigs' kidneys early after autotransplantation procedure.
  3. These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.
    Title: Molecular cloning and functional characterization of porcine MyD88 essential for TLR signaling.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables TIR domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Toll-like receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myeloid differentiation primary response protein MyD88
Names
myeloid differentiation primary response 88
myeloid differentiation primary response gene (88)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099923.1 → NP_001093393.1  myeloid differentiation primary response protein MyD88

    See identical proteins and their annotated locations for NP_001093393.1

    Status: PROVISIONAL

    Source sequence(s)
    EF198416
    UniProtKB/Swiss-Prot
    A2TF48, A7UL70, A8I488, B1B361, C6ZCT2
    UniProtKB/TrEMBL
    A0A4P8ET58
    Related
    ENSSSCP00000011996.4, ENSSSCT00000012318.6
    Conserved Domains (2) summary
    smart00255
    Location:158 → 293
    TIR; Toll - interleukin 1 - resistance
    cd08312
    Location:29 → 106
    Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

    Range
    22976951..22979568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2TF48.2 GenPept UniProtKB/Swiss-Prot:A2TF48

Gene LinkOut

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