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Toll-6 Toll-6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39663, updated on 4-Jan-2025

Summary

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Official Symbol
Toll-6provided by FlyBase
Official Full Name
Toll-6provided by FlyBase
Primary source
FLYBASE:FBgn0036494
Locus tag
Dmel_CG7250
See related
AllianceGenome:FB:FBgn0036494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
18w-like; CG7250; CT22359; Dmel\CG7250; dTLR6; dToll6; Tl-6; toll; Toll; Toll 6; TOLL 6; toll-6; Toll6
Summary
Enables neurotrophin receptor activity. Involved in several processes, including axis elongation; convergent extension; and dendrite guidance. Predicted to be located in membrane. Is expressed in several structures, including adult olfactory antennal lobe glomerulus; anlage in statu nascendi; brain; head epidermis primordium; and motor neurons. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Toll-6 in Genome Data Viewer
Location:
71C2-71C2; 3-43 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15336692..15344315)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15329792..15337415)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43247 Neighboring gene long non-coding RNA:CR43992 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43625

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct expression patterns detected within individual tissues by the GAL4 enhancer trap technique. Gustafson K, et al. Genome, 1996 Feb. PMID 8851804
  2. Electrophysiological correlates of rest and activity in Drosophila melanogaster. Nitz DA, et al. Curr Biol, 2002 Nov 19. PMID 12445387
  3. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Wittmann CW, et al. Science, 2001 Jul 27. PMID 11408621
  4. Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila. Yeh E, et al. Proc Natl Acad Sci U S A, 1995 Jul 18. PMID 7624365, Free PMC Article
  5. A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons. McLaughlin CN, et al. J Cell Biol, 2016 Aug 15. PMID 27502486, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Toll-6 and Spz are a new pair of guidance molecules mediating organ-specific metastatic behavior.
    Title: Spz/Toll-6 signal guides organotropic metastasis in Drosophila.
  2. elevated expression of Pav-KLP underlies transport and plasticity phenotypes in pathway mutants, indicating that Toll-6-FoxO signaling promotes MT dynamics by limiting Pav-KLP expression.
    Title: A Toll receptor-FoxO pathway represses Pavarotti/MKLP1 to promote microtubule dynamics in motoneurons.
  3. This study demonistrated that Toll-6 have neurotrophic functions in the Drosophila CNS matching those of DNT1 and DNT2 also pleiotropic functions, maintaining predominantly interneuron survival and regulating motor-axon targeting.
    Title: Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurotrophin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axis elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in convergent extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dendrite guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic plasticity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Toll-6
Names
CG7250-PA
CG7250-PB
CG7250-PC
Toll-6-PA
Toll-6-PB
Toll-6-PC
toll receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15336692..15344315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259837.3 → NP_001246766.1  Toll-6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246766.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NN49, Q9NBK9, Q9VUN0
    Conserved Domains (5) summary
    smart00255
    Location:1114 → 1247
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:350 → 729
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:401 → 626
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:279 → 302
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:883 → 943
    LRR_8; Leucine rich repeat

  2. NM_001259836.2 → NP_001246765.1  Toll-6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246765.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NN49, Q9NBK9, Q9VUN0
    Conserved Domains (5) summary
    smart00255
    Location:1114 → 1247
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:350 → 729
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:401 → 626
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:279 → 302
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:883 → 943
    LRR_8; Leucine rich repeat

  3. NM_079357.4 → NP_524081.1  Toll-6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524081.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NN49, Q9NBK9, Q9VUN0
    Related
    FBpp0075367
    Conserved Domains (5) summary
    smart00255
    Location:1114 → 1247
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:350 → 729
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:401 → 626
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:279 → 302
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:883 → 943
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95RV9 Q95RV9
Q9VUN0.1 Q9VUN0

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