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Prx1 Peroxiredoxin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39658, updated on 9-Dec-2024

Summary

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Official Symbol
Prx1provided by FlyBase
Official Full Name
Peroxiredoxin 1provided by FlyBase
Primary source
FLYBASE:FBgn0036490
Locus tag
Dmel_CG6888
See related
AllianceGenome:FB:FBgn0036490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6888; BcDNA:AT16346; CG6888; Dmel\CG6888; dPrx1
Summary
Enables peroxiredoxin activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and removal of superoxide radicals. Predicted to be located in cytoplasm and extracellular exosome. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Prx1 in Genome Data Viewer
Location:
71B8-71B8; 3-42 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15207844..15208586)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15200944..15201686)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44562 Neighboring gene tollo Neighboring gene Bestrophin 4 Neighboring gene Bestrophin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hyperoxidation of Peroxiredoxins and Effects on Physiology of Drosophila. McGinnis A, et al. Antioxidants (Basel), 2021 Apr 15. PMID 33920774, Free PMC Article
  2. Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Wangler MF, et al. Protein Cell, 2011 Jul. PMID 21822800, Free PMC Article
  3. Peroxiredoxins are conserved markers of circadian rhythms. Edgar RS, et al. Nature, 2012 May 16. PMID 22622569, Free PMC Article
  4. Genome wide analysis of common and specific stress responses in adult drosophila melanogaster. Girardot F, et al. BMC Genomics, 2004 Sep 30. PMID 15458575, Free PMC Article
  5. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxiredoxin activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
peroxiredoxin 1
Names
CG6888-PA
Prx1-PA
NP_648759.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15207844..15208586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140502.3 → NP_648759.1  peroxiredoxin 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648759.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUM4
    Related
    FBpp0075397
    Conserved Domains (2) summary
    COG0450
    Location:3 → 194
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:6 → 177
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUM4 Q9VUM4

Gene LinkOut

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