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Msh6 Msh6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39654, updated on 4-Jan-2025

Summary

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Official Symbol
Msh6provided by FlyBase
Official Full Name
Msh6provided by FlyBase
Primary source
FLYBASE:FBgn0036486
Locus tag
Dmel_CG7003
See related
AllianceGenome:FB:FBgn0036486
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7003; Dmel\CG7003; MSH6
Summary
Predicted to enable ATP hydrolysis activity and mismatched DNA binding activity. Involved in meiotic mismatch repair. Predicted to be part of MutSalpha complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Msh6 in Genome Data Viewer
Location:
71B6-71B6; 3-42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15154233..15158562, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15147333..15151662, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45397 Neighboring gene uncharacterized protein Neighboring gene Peroxin 3 Neighboring gene alpha1,3-fucosyltransferase A Neighboring gene Pre-mRNA processing factor 31 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of Drosophila mismatch repair in suppressing recombination between diverged sequences. Do AT, et al. Sci Rep, 2015 Nov 30. PMID 26616528, Free PMC Article
  2. Mismatch repair systems might facilitate the chromosomal recombination induced by N-nitrosodimethylamine, but not by N-nitrosodiethylamine, in Drosophila. Negishi T, et al. Mutagenesis, 2020 Mar 27. PMID 32109288
  3. Meiotic recombination in Drosophila Msh6 mutants yields discontinuous gene conversion tracts. Radford SJ, et al. Genetics, 2007 May. PMID 17339220, Free PMC Article
  4. Eliminating both canonical and short-patch mismatch repair in Drosophila melanogaster suggests a new meiotic recombination model. Crown KN, et al. PLoS Genet, 2014 Sep. PMID 25188408, Free PMC Article
  5. DNA mismatch repair and mutation avoidance pathways. Marti TM, et al. J Cell Physiol, 2002 Apr. PMID 11920679

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables mismatched DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in meiotic mismatch repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MutSalpha complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Msh6
Names
CG7003-PA
Msh6-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15154233..15158562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140498.2 → NP_648755.1  Msh6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648755.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6IDV3, Q9VUM0
    Related
    FBpp0075399
    Conserved Domains (7) summary
    cd03286
    Location:924 → 1140
    ABC_MSH6_euk; ATP-binding cassette domain of eukaryotic MutS6 homolog
    COG0249
    Location:261 → 1186
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam01624
    Location:263 → 375
    MutS_I; MutS domain I
    pfam05188
    Location:391 → 508
    MutS_II; MutS domain II
    pfam05190
    Location:767 → 859
    MutS_IV; MutS family domain IV
    pfam05192
    Location:584 → 667
    MutS_III; MutS domain III
    cl00788
    Location:44 → 156
    MttA_Hcf106; mttA/Hcf106 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUM0.2 Q9VUM0

Gene LinkOut

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