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Cep135 - Centrosomal protein 135kDa

Enables microtubule binding activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of microtubule depolymerization; and non-motile cilium assembly. Located in ciliary transition zone and microtubule organizing center. Is expressed in embryonic brain; larval ventral nerve cord; organism; and spermatozoon. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8 and spermatogenic failure 26. Orthologous to several human genes including CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa